{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:07:48Z","timestamp":1788260868209,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Merkel cell carcinoma (MCC) is a dermal neuroendocrine malignancy driven by inactivation of the tumor suppressors Rb and p53 either through Merkel cell polyomavirus (MCPyV) infection or ultraviolet (UV)\u2010induced mutations. Virus\u2010positive MCC exhibits pure neuroendocrine morphology, low UV\u2010induced mutational burden, retained Rb protein, and low p53 expression. Viral\u2010negative MCC includes pure neuroendocrine carcinomas and combined tumors with squamous and neuroendocrine components. These tumors typically exhibit loss of Rb expression and either overexpression of mutated p53 or a complete absence of p53. Intraepidermal, in\u00a0situ MCC (MCCis) is a rare, primarily viral\u2010negative variant that often coexists with actinic keratosis (AK) and squamous cell carcinoma in\u00a0situ (SCCis), supporting a UV\u2010driven pathogenesis. While MCCis is hypothesized as a potential precursor to select cases of combined MCC, its p53 and Rb expression remain largely uncharacterized. We report a CM2B4\u2010negative MCCis in an 87\u2010year\u2010old man associated with AK and SCCis. Compared to normal epidermis, AK and SCCis exhibited increased Rb and p53 expression, whereas MCCis demonstrated loss of expression of both tumor suppressors. These findings suggest that dual downregulation of Rb and p53 may drive select cases of MCCis in sun\u2010damaged skin.<\/jats:p>","DOI":"10.1111\/cup.70073","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T12:23:09Z","timestamp":1771417389000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lack of Rb and\n                    <scp>p53<\/scp>\n                    Expression in a Case of\n                    <scp>CM2B4<\/scp>\n                    Negative Merkel Cell Carcinoma In\u00a0Situ Associated With Squamous Dysplasia"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-0899","authenticated-orcid":false,"given":"Austinn C.","family":"Miller","sequence":"first","affiliation":[{"name":"University of Central Florida HCA Florida Healthcare Graduate Medical Education  Tallahassee Florida USA"},{"name":"Dermatology 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