{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:05:25Z","timestamp":1779246325410,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Palmoplantar epidermoid cysts are typically benign lesions associated with trauma or eccrine duct hypertrophy, occasionally associated with human papillomavirus (HPV) infection, particularly HPV60. Malignant transformation into squamous cell carcinoma (SCC) within these cysts is extremely rare. A 21\u2010year\u2010old Japanese woman presented with a slowly enlarging 1.0\u2009cm lesion on her left sole. Ultrasonography suggested a benign cystic lesion, and excisional biopsy was performed. Histopathology revealed an epidermoid cyst with koilocytosis, inclusion bodies, and focal SCC in\u00a0situ characterized by atypical squamous epithelial proliferation. Immunohistochemical staining showed diffuse p16 positivity, partial Rb loss, and a high Ki67 index in the SCC in\u00a0situ component. Anti\u2010HPV antibody (K1H8) was positive in the cyst wall but negative in the SCC in\u00a0situ. RNAscope analysis demonstrated HPV60\u2010E6\/E7 mRNA expression within the SCC in\u00a0situ, raising the possibility of HPV\u2010associated oncogenesis. These findings suggest a potential link between low\u2010risk HPV60 and cutaneous oncogenesis, emphasizing the need for thorough histopathological evaluation of plantar epidermoid cysts, even in young patients.<\/jats:p>","DOI":"10.1111\/cup.70082","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:39:50Z","timestamp":1773103190000},"page":"506-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Squamous Cell Carcinoma In\u00a0Situ Arising From\n                    <scp>HPV60<\/scp>\n                    \u2010Related Plantar Epidermoid Cyst"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9348-6217","authenticated-orcid":false,"given":"Ryosuke","family":"Masuyuki","sequence":"first","affiliation":[{"name":"Department of Dermatology Takagi Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-2036","authenticated-orcid":false,"given":"Kazushi","family":"Anzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Takase","sequence":"additional","affiliation":[{"name":"Department of Pathology Takagi Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1987-5942","authenticated-orcid":false,"given":"Tsubasa","family":"Hiraki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto\u2010gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto\u2010gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-079X","authenticated-orcid":false,"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Uchinada Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06562.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04400.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.08.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318220e59d"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199904000-00012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1383(94)90117-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1054779"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T02:05:52Z","timestamp":1779242752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/cup.70082"],"URL":"https:\/\/doi.org\/10.1111\/cup.70082","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"2025-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}