{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:18:14Z","timestamp":1783473494621,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Median canaliform dystrophy (MCD) of Heller is a rare nail disorder characterized by a median split and obliquely running furrows of the nail plate, often presenting in a \u201cfir\u2010tree\u201d pattern. While its pathogenesis remains poorly understood, proposed etiologies include habitual trauma, iatrogenic causes, and familial predisposition. Diagnosis is generally made by clinical evaluation. There is a paucity of data regarding the histopathology of MCD. Herein, we present two cases of MCD with novel histopathologic features, broadening the understanding of the pathophysiology and potential therapeutic options for this condition. In Case 1, histopathologic evaluation revealed mild spongiosis, suggesting an inflammatory etiology. Case 2 demonstrated distinctive acantholysis. These findings suggest that MCD encompasses a spectrum of histopathologic changes. Our report contributes to the limited histopathologic characterization of MCD.<\/jats:p>","DOI":"10.1111\/cup.70103","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:27:20Z","timestamp":1774931240000},"page":"678-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Histopathologic Features of Median Canaliform Dystrophy"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2280-9791","authenticated-orcid":false,"given":"Carli","family":"Tucci","sequence":"first","affiliation":[{"name":"New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-3767","authenticated-orcid":false,"given":"Gillian K.","family":"Weston","sequence":"additional","affiliation":[{"name":"Department of Dermatology UConn Health  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Sloan","sequence":"additional","affiliation":[{"name":"Department of Dermatology UConn Health  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maressa C.","family":"Criscito","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine  New York New York USA"},{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-1817","authenticated-orcid":false,"given":"Adam I.","family":"Rubin","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine  New York New York USA"},{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2022.08.051"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/680163"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15181"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13257"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"161","article-title":"Familial Median Canaliform Nail Dystrophy","volume":"75","author":"Sweeney S. A.","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196509000-00016"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.25259\/JONS_8_2025"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105154.174092"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12377"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70103","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70103","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:00:23Z","timestamp":1783472423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cup.70103"],"URL":"https:\/\/doi.org\/10.1111\/cup.70103","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}