{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:18:22Z","timestamp":1783473502314,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lichen planopilaris (LPP) is an autoimmune cicatricial alopecia leading to irreversible follicular destruction. Interleukin\u201031 (IL\u201031) and its receptor complex (IL\u201031RA\/OSMR\u03b2) are implicated in neurogenic inflammation and pruritus in inflammatory dermatoses, including lichen planus. This study aimed to evaluate IL\u201031\/IL\u201031RA expression in LPP and to investigate their associations with disease extent and pruritus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients with classical\u2010type LPP and 30 age\u2010 and sex\u2010matched controls were retrospectively analyzed. Disease extent and pruritus severity were assessed using the scalp involvement score (SALT) and the Numerical Rating Scale (NRS). Immunohistochemical staining was performed on scalp biopsy specimens. Quantitative analysis was conducted using the Sectra UniView digital pathology system and ImageJ\/Fiji software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201031\/IL\u201031RA expression levels were increased in both epidermal and dermal compartments of LPP lesions compared with controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Strong positive correlations were observed between epidermal and dermal IL\u201031\/IL\u201031RA expression levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant associations were detected between IL\u201031\/IL\u201031RA expression and SALT or NRS scores, whereas dermal IL\u201031RA levels were higher in patients with perifollicular scaling (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that increased IL\u201031 and IL\u201031RA expression in LPP is associated with neuroimmune signaling pathways involved in disease pathophysiology. Rather than indicating a disease\u2010defining or diagnostic mechanism, IL\u201031\/IL\u201031RA expression may represent an adjunctive immunologic feature within the broader inflammatory milieu of LPP and warrants further investigation in therapeutic and comparative studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70115","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:46:31Z","timestamp":1775713591000},"page":"741-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of\n                    <scp>IL<\/scp>\n                    \u201031 and\n                    <scp>IL<\/scp>\n                    \u2010\n                    <scp>31RA<\/scp>\n                    Expression in Lichen Planopilaris: A Retrospective Immunohistochemistry Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-5662","authenticated-orcid":false,"given":"\u00d6yk\u00fc","family":"G\u00f6n\u00fcll\u00fc","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozan","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0131d\u0131ka \u015eeyma","family":"\u00d6zkanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pathology Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcldehan","family":"At\u0131\u015f","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Memorial 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