{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:04Z","timestamp":1785779704404,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder affecting apocrine gland\u2013bearing areas. We report a 38\u2010year\u2010old male with a lesion in the left axilla, initially clinically interpreted as HS and resistant to antibiotics. Surgical excision and biopsy revealed a dense dermal and subcutaneous infiltrate of large atypical lymphoid cells with strong and diffuse CD30 expression (~80%\u201390% of tumor cells), CD4 positivity, ALK\u2010negativity, and loss of pan\u2013T\u2010cell markers, consistent with anaplastic large cell lymphoma (ALCL). While the lesion was initially considered primary cutaneous, regional lymph node involvement and FDG\u2010avid sites on PET created diagnostic uncertainty regarding systemic disease. The patient received multi\u2010agent systemic chemotherapy followed by autologous stem cell transplantation, achieving complete metabolic remission. This case highlights the histopathologic challenges of diagnosing CD30\u2010positive lymphoid infiltrates in the context of chronic inflammatory skin disease, particularly when lesions are initially clinically misinterpreted as benign inflammatory conditions such as HS. Recognition of diffuse CD30 positivity, cytologic atypia, subcutaneous involvement, and loss of pan\u2010T\u2010cell markers is critical for distinguishing malignant from reactive lymphoid infiltrates. Early biopsy, immunophenotypic analysis, and clinicopathologic correlation are essential to guide appropriate management in atypical or treatment\u2010resistant lesions. Rather than demonstrating a novel association with HS, this report emphasizes diagnostic and classification challenges at the interface between primary cutaneous and systemic ALCL, which are of direct relevance to cutaneous pathologists.<\/jats:p>","DOI":"10.1111\/cup.70124","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:01:11Z","timestamp":1776862871000},"page":"809-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse\n                    <scp>CD30<\/scp>\n                    \u2010Positive Cutaneous Infiltrate in a Clinically Suspected Hidradenitis Suppurativa Lesion: Histopathologic and Diagnostic Challenges"],"prefix":"10.1111","volume":"53","author":[{"given":"R.","family":"Gervasi","sequence":"first","affiliation":[{"name":"UOC Endocrine Surgery, AOU Dulbecco  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. L.","family":"Piazzetta","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery University \u201cMagna Gr\u00e6cia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Soluri","sequence":"additional","affiliation":[{"name":"UOC Endocrine Surgery, AOU Dulbecco  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Scigliano","sequence":"additional","affiliation":[{"name":"UOC General Surgery, AO San Giovanni di Dio  Crotone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-7367","authenticated-orcid":false,"given":"C.","family":"Pelaia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zuccal\u00e0","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adult and Developmental Age \u201cGaetano Barresi,\u201d Section of Pathology University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gentile","sequence":"additional","affiliation":[{"name":"Service's Department, Section of Anatomic Pathology A.O.U. Renato Dulbecco  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lobello","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery University \u201cMagna Gr\u00e6cia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-4333","authenticated-orcid":false,"given":"E.","family":"Allegra","sequence":"additional","affiliation":[{"name":"Otolaryngology Department of Health Science Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-715X","authenticated-orcid":false,"given":"E.","family":"Chiarella","sequence":"additional","affiliation":[{"name":"Laboratory of Morphology and Tissue Cellular Biology, Department of Medical and Surgical Sciences Magna Graecia University of Catanzaro  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Innaro","sequence":"additional","affiliation":[{"name":"UOC Endocrine Surgery, AOU Dulbecco  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2020.1422"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMADERMATOL.2018.5230"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.09.012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE01322"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.045"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2018.02965"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2382372"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES9111594"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S512373"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/AJH.26760"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.4026"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.12701\/yujm.2020.00801"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16234085"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7156"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.11.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17268.2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13894"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13030823"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:24:09Z","timestamp":1785777849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/cup.70124"],"URL":"https:\/\/doi.org\/10.1111\/cup.70124","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}