{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:55:03Z","timestamp":1785779703182,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is a rare, aggressive subtype of B\u2010cell non\u2010Hodgkin lymphoma with rare cutaneous involvement that typically indicates advanced systemic disease. We report a case of indolent MCL in a 56\u2010year\u2010old previously healthy male who presented with a 5\u2010year history of edematous, painful plaques and associated onychodystrophy in the bilateral toes. Histopathology demonstrated a multinodular dermal and subcutaneous infiltrate of atypical lymphocytes. Immunohistochemistry revealed a primary B\u2010cell population diffusely positive for CD20 and BCL2 and focally positive for BCL1. These cells were negative for CD5, SOX\u201011, BCL6, and LEF1. In\u00a0situ hybridization demonstrated admixed lambda\u2010restricted plasma cells, indicating plasmacytic differentiation. Fluorescence in\u00a0situ hybridization testing for an\n                    <jats:italic>IGH<\/jats:italic>\n                    \/\n                    <jats:italic>CCND1<\/jats:italic>\n                    translocation was positive, confirming a diagnosis of MCL. While bone marrow biopsy demonstrated 10%\u201320% involvement by MCL, staging revealed no lymphadenopathy or visceral disease. No significant peripheral blood laboratory abnormality was noted. To our knowledge, this is the first reported case of cutaneous involvement by MCL confined to the bilateral toes. This case is also notable for its absence of typical markers, namely CD5 and SOX\u201011, plasmacytic differentiation, and indolent clinical behavior. We discuss the diagnostic and clinical significance of these atypical clinicopathologic features and diagnostic overlap with other cutaneous B\u2010cell lymphomas, emphasizing the importance of comprehensive immunophenotypic and molecular evaluation in atypical presentations.\n                  <\/jats:p>","DOI":"10.1111\/cup.70125","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:27:08Z","timestamp":1776950828000},"page":"815-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Acral Presentation of Indolent Mantle Cell Lymphoma With Prominent Nail Involvement and Atypical Immunophenotype"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2669-770X","authenticated-orcid":false,"given":"Q. Wilton","family":"Sun","sequence":"first","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-837X","authenticated-orcid":false,"given":"Sebastian A.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-1104","authenticated-orcid":false,"given":"Joshua","family":"Menke","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7375-6878","authenticated-orcid":false,"given":"Brent","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri E.","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1382-743X","authenticated-orcid":false,"given":"Philip L.","family":"Bulterys","sequence":"additional","affiliation":[{"name":"Divisions of Dermatopathology and Hematopathology, Department of Pathology Massachusetts General Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2202672"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15570\/actaapa.2020.38"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001312"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001742"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.792"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19987"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225096"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001278"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010264"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001233"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201012\u20101615"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.2002317"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201012\u2010400580"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.03.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200608000\u201000004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.99"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024095"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13161"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:24:06Z","timestamp":1785777846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/cup.70125"],"URL":"https:\/\/doi.org\/10.1111\/cup.70125","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}