{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:12:28Z","timestamp":1780398748882,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The histologic diagnosis of alopecia can be challenging. Polarized light microscopy and diffractive microscopy can be performed without added cost or the need for special stains. We sought to determine if they can be of value in the diagnosis of alopecia biopsy specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 152 deidentified alopecia scalp biopsy slides (80 non\u2010scarring and 72 scarring) with polarized and diffractive microscopy and analyzed the performance of each method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fibrous tracts were evaluable in 150 of the 152 specimens. One was excluded as the dermis was completely replaced by scar and one demonstrated follicles but no empty fibrous tracts. Intensity of polarization and diffraction differed between scarring and non\u2010scarring alopecia, with clearer separation in polarized microscopy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with diffractive microscopy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). Polarized intensity showed good discrimination (\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      0.804) with high specificity (94.9%) and modest sensitivity (49.3%). In contrast, grading diffractive intensity added little to a simpler bimodal scale (\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      0.585). A circumferential perifollicular halo was more common in non\u2010scarring alopecia, especially androgenetic alopecia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Polarized light microscopy outperformed diffractive microscopy for distinguishing scarring from non\u2010scarring alopecia and provides a highly specific adjunct to simple microscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70152","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:27:16Z","timestamp":1780396036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polarized Versus Diffractive Microscopy in Distinguishing Scarring From Non\u2010Scarring Alopecia"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3438-8844","authenticated-orcid":false,"given":"Kerem","family":"Balan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Etimesgut Sehit Sait Erturk State Hospital  Ankara Turkiye"},{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Dermatology, Kuwait Jahra Hospital  Al Jahra Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik Sulaiman Al","family":"Nasseri","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Dermatology, Ar Rustaq Extended Health Center  Rustaq Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Pathology Salmaniya Medical Complex  Manama Kingdom of Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Dermatology Xiangya Hospital, Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"},{"name":"Department of Dermatology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Keller","sequence":"additional","affiliation":[{"name":"College of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-0425","authenticated-orcid":false,"given":"Maya","family":"Andrade","sequence":"additional","affiliation":[{"name":"College of Medicine Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk M.","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Dermatologic Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.2009.03439.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000973"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.02.030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.038"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12608"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_1185_23"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.344"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:27:17Z","timestamp":1780396037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":8,"alternative-id":["10.1111\/cup.70152"],"URL":"https:\/\/doi.org\/10.1111\/cup.70152","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"2025-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70152"}}