{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:24Z","timestamp":1792028724464,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report an unusual case of basal cell carcinoma (BCC) with ductal differentiation presenting as a large unilocular cyst on the abdomen of an 83\u2010year\u2010old Japanese man. An initial punch biopsy showed part of the bilayered cyst wall, suggesting a sweat gland neoplasm. However, complete excision revealed a unilocular cyst continuous with underlying basaloid tumor nests showing peripheral palisading, stromal clefting, and partial BerEP4 expression, consistent with BCC. Both the luminal and outer layers of the cyst also showed partial BerEP4 expression. The luminal layer was positive for epithelial membrane antigen (EMA) and carcinoembryonic antigen, indicating that the unilocular cyst was a genuine cyst rather than a pseudocyst secondary to mucin deposition or tumor necrosis. The outer layer lacked myoepithelial markers including SRY\u2010box transcription factor 10 and smooth muscle actin, suggesting that it represented part of the BCC rather than myoepithelium. Overall, we diagnosed the lesion as BCC with ductal differentiation forming a cyst with an EMA\u2010positive lining. BCC with ductal differentiation has been reported, but cases with large unilocular cysts are uncommon. This case broadens the histologic spectrum of BCC and emphasizes the importance of complete excision and comprehensive immunohistochemical analysis in cystic lesions to avoid misdiagnosis.<\/jats:p>","DOI":"10.1111\/cup.70157","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:57:07Z","timestamp":1780113427000},"page":"1021-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basal Cell Carcinoma With Ductal Differentiation Presenting as a Large Unilocular Cyst on the Abdomen"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4612-9789","authenticated-orcid":false,"given":"Atsushi","family":"Naito","sequence":"first","affiliation":[{"name":"Department of Dermatology Tenri Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tenri Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-6142","authenticated-orcid":false,"given":"Takaya","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Fukumoto Dermatopathology Clinic  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tenri Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6506-0811","authenticated-orcid":false,"given":"Hiroshi","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tenri Hospital  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"903","volume-title":"Weedon's Skin Pathology","author":"Weedon D.","year":"2025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.02.006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3820"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-45704-8_34"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"383","article-title":"Basal Cell Carcinoma With Ductal and Glandular Differentiation: A Clinicopathological and Immunohistochemical Study of 10 Cases","volume":"14","author":"Misago N.","year":"2004","journal-title":"European Journal of Dermatology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/dermatopathology11040032"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.12.2011.5307"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01494.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2024.04.008"},{"issue":"5","key":"e_1_2_10_11_1","article-title":"Eccrine Hidrocystoma of the Central Chest and Dermoscopic Findings","volume":"12","author":"Zanot A. M.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100265"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14543"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"161","article-title":"Zur Morphogenese Der Basaliome","volume":"231","author":"Hundeiker M.","year":"1968","journal-title":"Archives of Clinical and Experimental Dermatology"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"99","article-title":"Basal Cell Carcinoma Develops in Contact With the Epidermal Basal Cell Layer \u2010 a Three\u2010Dimensional Morphological Study","volume":"57","author":"Pirici I.","year":"2016","journal-title":"Romanian Journal of Morphology and Embryology"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001042"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:08:36Z","timestamp":1792026516000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/cup.70157"],"URL":"https:\/\/doi.org\/10.1111\/cup.70157","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}