{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:29Z","timestamp":1792028729910,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The mitogen\u2010activated protein kinase (MAPK) pathway plays a key role in cell\u2010cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan\u2010RAS (RMC\u20106236) and pan\u2010RAF (LXH254\/naporafenib) inhibitors are emerging. Therefore, knowledge of the morphologic patterns of DTs from pan\u2010RAS\/RAF inhibitors will enable quick diagnosis and appropriate management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The clinical and histologic features of patients treated with pan\u2010RAS or pan\u2010RAF inhibitors for advanced stage\n                      <jats:italic>RAS<\/jats:italic>\n                      mutated malignancies were retrospectively reviewed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Associated DTs were identified in eight patients treated with either pan\u2010RAS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) or pan\u2010RAF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) plus MEK\/ERK inhibitors for\n                      <jats:italic>RAS<\/jats:italic>\n                      mutated tumors (colorectal, lung, pancreatic, thyroid, melanoma). The patients ranged from 37 to 72\u2009years of age. Five patients had initial clinical presentation of an acneiform eruption complicated by ulceration, flaccid vesicles, or diffuse exfoliative erythroderma. Maculopapular eruption, purpuric patches and papules, and eruptive dark nevi were the other clinical presentations. Skin biopsies were primarily inflammatory with histopathologic features of suppurative folliculitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), dermal hypersensitivity reaction (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), subcorneal acantholytic dermatosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), subcorneal pustules (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), ulcer (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), and eruptive nevi (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with novel pan\u2010RAS\/RAF inhibitors exhibits a spectrum of DTs that exhibit some overlap with small molecule inhibitors that target the MAPK pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70159","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:23:09Z","timestamp":1780636989000},"page":"1042-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dermatologic Toxicities Associated With Novel Pan\u2010\n                    <scp>RAS<\/scp>\n                    \/\n                    <scp>RAF<\/scp>\n                    Inhibitors"],"prefix":"10.1111","volume":"53","author":[{"given":"Lin J.","family":"He","sequence":"first","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaymaa","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyu P.","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadharsini","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7346-8809","authenticated-orcid":false,"given":"Fiorinda","family":"Muhaj","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne N.","family":"Choksi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly C.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doina","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-0661","authenticated-orcid":false,"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-7161","authenticated-orcid":false,"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas 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