{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:02:45Z","timestamp":1781013765621,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Molecular analysis has emerged as an important ancillary method for the diagnosis and treatment of melanocytic tumors. Test results are often helpful but can occasionally be confounding if an unfamiliar variant is identified. We report a series of melanocytic tumors, which were found to harbor a\n                    <jats:italic>TFG<\/jats:italic>\n                    gene fusion and their significance. Of 105 melanocytic tumors with gene fusions, 9 involved\n                    <jats:italic>TGF (8.6%)<\/jats:italic>\n                    . One tumor harbored a\n                    <jats:italic>TFG::NTRK3<\/jats:italic>\n                    fusion, more precisely characterized as an\n                    <jats:italic>NTRK3<\/jats:italic>\n                    fusion with\n                    <jats:italic>TFG<\/jats:italic>\n                    as the 5\u2032 partner, the detection of which was diagnostically helpful by indicating the presence of a Spitz pathway. Eight cases exhibited a\n                    <jats:italic>TFG::ADGRG7<\/jats:italic>\n                    fusion. Current evidence suggests that this recurrent event represents a polymorphic germline variant, possibly arising from read\u2010through transcription (intergenic splicing), rather than a biologically pathogenic driver. It should be noted that laboratory reporting practices vary, and not all laboratories report such transcripts in official molecular pathology reports. Recognition of such fusions is essential to avoid misinterpretation, particularly as fusion detection increasingly informs diagnosis and clinical decision\u2010making. These findings underscore the necessity of integrating molecular results with established clinicopathologic frameworks.\n                  <\/jats:p>","DOI":"10.1111\/cup.70162","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:34:16Z","timestamp":1781012056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>TFG<\/i>\n                    <\/scp>\n                    \u2010Containing Fusions in Melanocytic Tumors: From Polymorphic Read\u2010Through Transcripts to Oncogenic Kinase Fusions"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-349X","authenticated-orcid":false,"given":"Haiming","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"DiNapoli","sequence":"additional","affiliation":[{"name":"Melanoma Research Alliance  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-0871","authenticated-orcid":false,"given":"Purvil","family":"Sukhadia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-6052","authenticated-orcid":false,"given":"David","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-9601","authenticated-orcid":false,"given":"Klaus J.","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"147","article-title":"From Basic Research to the Clinic: The Molecular Landscape of Melanoma and Its Effector Pathways","volume":"48","author":"Shain A. 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Adhesion G Protein\u2010Coupled Receptors","volume":"67","author":"Hamann J.","year":"2015","journal-title":"Pharmacological Reviews"},{"issue":"2","key":"e_1_2_10_16_1","first-page":"108620","article-title":"Discovery of Novel Chimeric RNAs in Normal and Cancer Tissues Using Large\u2010Scale RNA\u2010Seq Data","volume":"34","author":"Qin F.","year":"2021","journal-title":"Cell Reports"},{"issue":"6","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1093\/nar\/gkw032","article-title":"Recurrent Chimeric Fusion RNAs in Non\u2010Cancer Tissues and Cells","volume":"44","author":"Babiceanu M.","year":"2016","journal-title":"Nucleic Acids Research"},{"issue":"2","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10549-014-3019-2","article-title":"Recurrent Read\u2010Through Fusion Transcripts in Breast Cancer","volume":"146","author":"Varley K. 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