{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:55:59Z","timestamp":1781790959133,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life\u2010threatening mucocutaneous reactions most commonly triggered by medications. While cytotoxic T\u2010cell\u2013mediated keratinocyte death is considered central to disease pathogenesis, the contribution of innate immune pathways, particularly NLRP1\u2010mediated inflammasome activation, remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed skin biopsy specimens from 22 patients with histopathologically confirmed SJS\/TEN and 18 controls with normal skin. Immunohistochemical staining for NLRP1 and IL\u20101\u03b2 was semiquantitatively assessed using H\u2010scores, and clinical features including suspected triggers, SCORTEN, and outcomes were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NLRP1 and IL\u20101\u03b2 expression in both epidermal keratinocytes and dermal lymphocytes was significantly elevated in SJS\/TEN compared with controls (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and NLRP1 levels demonstrated a strong positive correlation with SCORTEN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant differences in expression were observed between survivors and non\u2010survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings support a role for inflammasome activation in SJS\/TEN pathogenesis and suggest that NLRP1 may serve as a potential biomarker of disease severity. Larger, prospective studies are warranted to confirm these observations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70166","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:49:21Z","timestamp":1781790561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated\n                    <scp>NLRP1<\/scp>\n                    and\n                    <scp>IL<\/scp>\n                    \u20101\u03b2 Expression Supports Inflammasome Activation in\n                    <scp>SJS<\/scp>\n                    \/\n                    <scp>TEN<\/scp>"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-1245","authenticated-orcid":false,"given":"Merve","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Dermatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4761-965X","authenticated-orcid":false,"given":"Burak","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine John H. Stroger, Jr. Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-6109","authenticated-orcid":false,"given":"K\u00fcbra","family":"Katipoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-2248","authenticated-orcid":false,"given":"Funda","family":"Erduran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Immunology Istanbul Faculty of Medicine, Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuran","family":"S\u00fcng\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pathology Ankara Bilkent City Hospital  Ankara 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