{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:44:11Z","timestamp":1782960251307,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematopoietic neoplasm of immature plasmacytoid dendritic cells. Before the cell of origin was elucidated, it was previously termed \u201cCD4+\/CD56+ hematodermic neoplasm,\u201d \u201cagranular CD4+ natural killer (NK) cell leukemia,\u201d \u201cblastic NK\u2010cell lymphoma,\u201d and \u201cblastic NK leukemia\/lymphoma.\u201d While there is a high frequency of concurrent cutaneous and bone marrow involvement at presentation, some cases may present with disease localized to the skin. Since the most common site of involvement is the skin, the diagnosis is generally made via skin biopsy. However, limited experience with this rare entity may lead to diagnostic delay. The histopathologic, immunohistochemical, and molecular findings as well as the current diagnostic criteria for BPDCN are reviewed. In addition, the differential diagnosis with acute myeloid leukemia with CD4\/CD56\/CD123 positivity and reactive plasmacytoid dendritic cell hyperplasia is discussed.<\/jats:p>","DOI":"10.1111\/cup.70168","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:06:36Z","timestamp":1782957996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blastic Plasmacytoid Dendritic Cell Neoplasm"],"prefix":"10.1111","author":[{"given":"Antonio","family":"Subtil","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Haematolymphoid Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2024"},{"key":"e_1_2_11_3_1","volume-title":"International Consensus Classification of Myeloid and Lymphoid Neoplasms","author":"Arber D. 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