{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:59:05Z","timestamp":1790629145745,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Melanocytic tumors are categorized into \u201ccommon,\u201d \u201cSpitz,\u201d and \u201cblue\u201d types based on distinct genetic profiles, as recognized in the latest WHO classification. In this report, we present the first case of a PRKCA\u2010fused blue melanocytoma ALK\u2010positive in a 13\u2010year\u2010old girl, who exhibited a dome\u2010shaped cutaneous lesion on the tibia. The tumor demonstrated an intriguing immunostaining with ALK1A4 antibody. Targeted RNA sequencing revealed a\n                    <jats:italic>PRKCA<\/jats:italic>\n                    fusion without\n                    <jats:italic>ALK<\/jats:italic>\n                    rearrangement. But, further investigations uncovered ALK alternative transcripts resulting from an alternative transcription initiation (ATI). While the\n                    <jats:italic>ALK<\/jats:italic>\n                    truncated isoform (\n                    <jats:italic>ALK<\/jats:italic>\n                    ATI) has been identified in a small subset of melanomas, its presence in Spitz or blue tumors has not previously been documented.\n                  <\/jats:p>","DOI":"10.1111\/cup.70171","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:10:14Z","timestamp":1783739414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A\n                    <scp>PRKCA<\/scp>\n                    \u2010Fused Blue Melanocytoma Expressing a Truncated\n                    <scp>ALK<\/scp>\n                    Isoform"],"prefix":"10.1111","author":[{"given":"Hadrien","family":"Reboul","sequence":"first","affiliation":[{"name":"Pathology Department University Hospital Center, IUCT\u2010University Cancer Institute  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Thibaut","sequence":"additional","affiliation":[{"name":"Pathology Center of Coteaux  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Galinier","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Office of the Rive Gauche Clinic  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Tournier","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital Center, IUCT\u2010University Cancer Institute  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grand","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital Center, IUCT\u2010University Cancer Institute  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Escudi\u00e9","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital Center, IUCT\u2010University Cancer Institute  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"de la Fourchardi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Biopathology Centre Leon Berard  Lyon France"},{"name":"Department of Research University of Lyon, Universite Claude Bernard Lyon 1, Cancer Research Centre of Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-7658","authenticated-orcid":false,"given":"Laurence","family":"Lamant","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital Center, IUCT\u2010University Cancer Institute  Toulouse France"},{"name":"Toulouse University  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100264"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15258"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000611"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010021\u201003227\u2010x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100286"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002262"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13100\u2010016\u20100080\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000674\u2010z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17\u201000548"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.31.596845"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201009\u20102845"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5411"},{"issue":"5","key":"e_1_2_9_14_1","first-page":"1057","article-title":"Nucleolar Localization of the Nucleophosmin\u2010Anaplastic Lymphoma Kinase is Not Required for Malignant Transformation","volume":"58","author":"Mason D. 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