{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:28:54Z","timestamp":1788276534637,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary cutaneous follicular helper T\u2010cell lymphoma (pcTFH\u2010L) is a rare, poorly characterized entity. We present six new cases to elucidate its clinicopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the clinical, histomorphological, and immunohistochemical features (TFH markers: PD\u20101, CXCL13, BCL\u20106, CD10, ICOS), EBV status, and T\u2010cell receptor clonality of six pcTFH\u2010L cases, comparing findings with 48 previously reported cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort (five males, one female; median age 66.5\u2009years, range 42\u201375\u2009years) presented with localized skin lesions without B symptoms or lymphadenopathy. All cases showed dermal\/subcutaneous infiltration by atypical lymphocytes without epidermotropism (nodular pattern in 4 cases, diffuse pattern in 2 cases). Prominent high endothelial venules (HEVs) were exhibited in 4\/6 cases. Neoplastic cells in all cases expressed CD4 and at least three TFH markers, with PD\u20101 (6\/6), ICOS (6\/6), and CXCL13 (6\/6) being the most sensitive. CD21\u2010positive follicular dendritic cell (FDC) networks were observed in 4 of 6 cases. Epstein\u2013Barr virus\u2010encoded RNA (EBER) was positive in 4 of 6 cases, and clonal T\u2010cell receptor (TCR) gene rearrangements were detected in all 6 cases tested. Treatments varied from none to combination chemotherapy, with outcomes ranging from stable disease to complete remission; one patient died of heart failure, and another died at 20\u2009months despite treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case series reinforces pcTFH\u2010L as a distinct cutaneous lymphoma with a characteristic immunophenotype and microenvironment. The consistent expression of multiple TFH markers, particularly PD\u20101, ICOS, and CXCL13, is essential for accurate diagnosis and differentiation from other cutaneous T\u2010cell lymphoproliferative disorders. The clinical course appears heterogeneous, with some cases showing indolent behavior while others may have more aggressive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70176","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:17:18Z","timestamp":1784661438000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Cutaneous Follicular Helper T\u2010Cell Lymphoma: A Clinicopathological Study of Six Cases and Review of the Literature"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-494X","authenticated-orcid":false,"given":"Jianlan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pathology Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University (Lymphoma Diagnostic Center, Beijing Institute of Clinical Medicine)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9638-4797","authenticated-orcid":false,"given":"Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Seventh Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-7103","authenticated-orcid":false,"given":"Xiaoge","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University (Lymphoma Diagnostic Center, Beijing Institute of Clinical Medicine)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-7619","authenticated-orcid":false,"given":"Yuanyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University (Lymphoma Diagnostic Center, Beijing Institute of Clinical Medicine)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-420X","authenticated-orcid":false,"given":"Yanlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing Friendship Hospital, the Second Clinical Medical College of Capital Medical University (Lymphoma Diagnostic Center, Beijing Institute of Clinical Medicine)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-7600","authenticated-orcid":false,"given":"Yunsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Seventh Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-5079","authenticated-orcid":false,"given":"Changfei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology The Seventh Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6103-4277","authenticated-orcid":false,"given":"Xiangyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Seventh Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000209855.28282.ce"},{"key":"e_1_2_9_4_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow S. 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