{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:00:58Z","timestamp":1785038458505,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Miliaria profunda is due to duct obstruction and rupture below the epidermis, with dermal sweat leakage associated and a variable inflammatory reaction. A rare but distinct presentation of miliaria profunda in infants is named giant centrifugal miliaria profunda (GCMP), showing centrifugal expansion of large, annular plaques. On histology, GCMP shows hyperkeratosis with ortho\u2010 and parakeratosis, and acanthosis with foci of intercellular edema. Acrosyringia are distended with obstruction by eosinophilic plugs of ortho\u2010parakeratotic material. Dermal ducts appear dilated and show squamous metaplasia. A periductal and peri\u2010eccrine variable inflammatory infiltrate contains neutrophils and often granulomatous inflammation is identified. We report two cases of GCMP, one of them associated with an MAP2K1 germinal RASopathy.<\/jats:p>","DOI":"10.1111\/cup.70179","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:23:48Z","timestamp":1785036228000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Centrifugal Miliaria Profunda"],"prefix":"10.1111","author":[{"given":"Ruth","family":"Alperovich","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Ni\u00f1o Jes\u00fas  Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0903-7734","authenticated-orcid":false,"given":"Anthony J.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Feinberg School of Medicine, Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Montanari","sequence":"additional","affiliation":[{"name":"Department of Genetics Hospital del Ni\u00f1o Jes\u00fas  Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-9237","authenticated-orcid":false,"given":"Joan","family":"Guitart","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine, Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6859-187X","authenticated-orcid":false,"given":"Isabel","family":"Colmenero","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-6916","authenticated-orcid":false,"given":"Antonio","family":"Torrelo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1525-1470.1990.tb00671.x","article-title":"Giant Centrifugal Miliaria Profunda","volume":"7","author":"Rogers M.","year":"1990","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1111\/j.1525-1470.2011.01666.x","article-title":"Granulomatous Variant of Giant Centrifugal Miliaria Profunda","volume":"30","author":"Doshi R.","year":"2013","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.4103\/idoj.IDOJ_422_18","article-title":"Chadha AA, Mahajan SA, Dongre A, Khopkar US. Granulomatous Variant of Giant Centrifugal Miliaria Profunda in a Hypothyroid Infant: A Case Report","volume":"10","year":"2019","journal-title":"Indian Dermatology Online Journal"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/pde.15827","article-title":"Granulomatous Variant of Giant Centrifugal Miliaria Profunda in an 8\u2010Month\u2010Old Boy: Expanding the Dermatologic Phenotype of Cardiofaciocutaneous Syndrome","volume":"42","author":"Tolson H. C.","year":"2025","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1525-1470.2009.00982.x","article-title":"Eccrine Squamous Metaplasia and Periadnexal Granulomas: New Cutaneous Histopathologic Findings in Cardiofaciocutaneous Syndrome","volume":"27","author":"Jeffries M. L.","year":"2010","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/pde.12171","article-title":"Cutaneous Manifestations in Costello and Cardiofaciocutaneous Syndrome: Report of 18 Cases and Literature Review","volume":"30","author":"Morice\u2010Picard F.","year":"2013","journal-title":"Pediatric Dermatology"},{"key":"e_1_2_8_8_1","first-page":"521","article-title":"Dermatological Findings in 61 Mutation\u2010Positive Individuals With Cardiofaciocutaneous Syndrome","volume":"164","author":"Siegel D. H.","year":"2011","journal-title":"British Journal of Dermatology"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:23:50Z","timestamp":1785036230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":7,"alternative-id":["10.1111\/cup.70179"],"URL":"https:\/\/doi.org\/10.1111\/cup.70179","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70179"}}