{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:45:25Z","timestamp":1785843925710,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Plaque\u2010like CD34\u2010positive dermal fibroma (PDF), which historically overlaps with medallion\u2010like dermal dendrocyte hamartoma (MDDH), is a rare benign CD34\u2010positive spindle\u2010cell lesion with highly variable clinicopathologic descriptions. We analyzed two adult\u2010onset cases and reviewed the published literature to determine whether reported PDF\/MDDH lesions cluster into reproducible clinicopathologic patterns. Our literature review comprises 25 cases. Comparative analyses revealed marked differences in age at onset, lesion size, anatomic distribution, depth of involvement, papillary dermis sparing, subcutaneous extension, and epidermal response. One pattern was characterized by early\u2010onset, larger plaque\u2010like lesions on the trunk or neck, with deep dermal to subcutaneous spindle\u2010cell proliferation and frequent epidermal atrophy (early\u2010onset deep pattern). The second pattern was characterized by adult\u2010onset, small papules or papuloplaques, predominantly on the extremities, featuring upper reticular dermal spindle\u2010cell proliferation, papillary dermis sparing, elongated rete ridges, and a perpendicular\u2010to\u2010horizontal spindle\u2010cell arrangement (adult\u2010onset superficial pattern). All lesions showed diffuse CD34 positivity. Lesions currently reported under the PDF\/MDDH umbrella appear to encompass two reproducible clinicopathologic patterns. Recognizing these patterns may improve diagnostic accuracy and facilitate the distinction of these lesions from dermatofibrosarcoma protuberans and other superficial CD34\u2010positive spindle\u2010cell proliferations.<\/jats:p>","DOI":"10.1111\/cup.70181","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:07:30Z","timestamp":1785841650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lesions Reported as Plaque\u2010Like\n                    <scp>CD34<\/scp>\n                    \u2010Positive Dermal Fibroma Reveal Two Reproducible Clinicopathologic Patterns: Two Cases and Literature Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8114-8290","authenticated-orcid":false,"given":"Wei","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pathology Shanghai Skin Disease Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-0769","authenticated-orcid":false,"given":"Mingyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Skin Disease Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-1390","authenticated-orcid":false,"given":"Yeqiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Skin Disease Hospital, School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.070"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181c7cf11"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2025.0745"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00552.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.03.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08896.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01324.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.3.382"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13766"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_12_2025"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.5070\/D34G90P66C"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90395-X"},{"key":"e_1_2_10_14_1","article-title":"Plaque\u2010Like CD34\u2010Positive Dermal Fibroma of the Toe: A Case Report and Review of the Literature","volume":"17","author":"Gagadam S.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.131110"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417722733"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.70120"}],"container-title":["Journal of Cutaneous 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