{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:48Z","timestamp":1785732408031,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frozen section analysis enables rapid diagnosis, but its diagnostic accuracy in the setting of severe cutaneous adverse reactions (SCARs) remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were performed to evaluate the diagnostic performance of frozen sections in the rapid identification of SCARs, with a focus on Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN), compared to paraffin\u2010embedded sections. Studies were identified from MEDLINE, EMBASE, the Cochrane Library, ISI Web of Science, and SCOPUS. Random\u2010effects models were used for meta\u2010analysis, and study quality was evaluated using the QUADAS\u20102 and STARD tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three diagnostic accuracy studies, comprising 134 patients, were eligible for meta\u2010analysis. For SJS\/TEN, pooled sensitivity was 0.91 (95% CI 0.83\u20130.96) and pooled specificity was 0.90 (95% CI 0.79\u20130.95), with a diagnostic odds ratio of 91.3 (95% CI 18.1\u2013460.6). The area under the summary receiver operative characteristic (sROC) curve was 0.957. Data for other SCAR subtypes were insufficient for pooled analysis. Turnaround times were inconsistently reported, and risk\u2010of\u2010bias assessments identified high risk in two studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frozen sections demonstrate high diagnostic accuracy for the rapid evaluation of SJS\/TEN, but the evidence is confined to a limited number of small, heterogeneous studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70185","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:35:43Z","timestamp":1785731743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Accuracy of Frozen Section Histopathology in the Rapid Diagnosis of Severe Cutaneous Adverse Reactions: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-2472","authenticated-orcid":false,"given":"Cody C.","family":"Frear","sequence":"first","affiliation":[{"name":"Faculty of Health, Medicine and Behavioural Sciences The University of Queensland  Herston Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Frear","sequence":"additional","affiliation":[{"name":"School of Exercise and Nutrition Sciences Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-6638","authenticated-orcid":false,"given":"Duncan","family":"Lambie","sequence":"additional","affiliation":[{"name":"Sullivan Nicolaides Pathology  Brisbane Australia"},{"name":"Frazer Institute, University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Godbolt","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women's Hospital  Brisbane 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Frozen Section Consultation: Concepts, Applications and Limitations","volume":"13","author":"Jaafar H.","year":"2006","journal-title":"Malays J Med Sci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.08.041"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14530"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2015.12.001"},{"issue":"3","key":"e_1_2_10_26_1","first-page":"218","article-title":"Spectrum of Morphological Changes in Erythema Multiforme","volume":"28","author":"Khan P.","year":"2020","journal-title":"Journal of Medical Sciences"}],"container-title":["Journal of Cutaneous 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