{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:27:14Z","timestamp":1786634834301,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Patients struggle to comprehend dermatopathology reports. As artificial intelligence (AI) tools become more accessible, patients may use them to interpret reports; however, optimal approaches remain unexplored.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n Evaluate whether prompt\u2010engineered AI simplification of dermatopathology reports improves factualness, completeness, and reduces potential harm compared to basic AI usage.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Survey\u2010based study (January\u2013April 2025) of 52 US dermatology and dermatopathology professionals (70.3% response rate). Six fictitious dermatopathology reports were simplified using: (1) Basic ChatGPT\u20104.0 with simple prompt and (2) Custom \u201cDermDecoder\u201d GPT with structured 489\u2010word prompt. Participants rated reports on 3\u2010point Likert scales for factualness, completeness, and potential harm, with free\u2010text responses analyzed thematically.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean ratings ranged from 1.27 to 1.63 (factualness\/completeness) and 1.31\u20131.83 (harmfulness), indicating \u201cAgree\u201d to \u201cMostly Agree\u201d or \u201cCompletely Harmless\u201d to \u201cMostly Harmless.\u201d DermDecoder performed significantly worse for completeness in psoriasis (\n t<\/jats:italic>\n \u2009=\u2009\u22122.79,\n p<\/jats:italic>\n \u2009=\u20090.007) and harmfulness in molluscum contagiosum (\n p<\/jats:italic>\n \u2009=\u20090.049) and melanoma in\u00a0situ (\n p<\/jats:italic>\n \u2009=\u20090.048). Free\u2010text analysis revealed Basic Prompt preserved details but lacked clinical context, while DermDecoder provided generic education disconnected from pathological findings.\n <\/jats:p>\n <\/jats:sec>\n \n Limitations<\/jats:title>\n Fictitious reports, small sample, evolving AI capabilities, and absence of patient perspectives.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Prompt engineering offered no advantage over basic AI usage in balancing professional accuracy with patient accessibility, necessitating human\u2010in\u2010the\u2010loop oversight for AI\u2010generated explanations.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cup.70187","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:28:37Z","timestamp":1786631317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AI<\/scp>\n Simplification of Dermatopathology Reports for Patients: Basic Versus Prompt\u2010Engineered Approaches"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2335-8780","authenticated-orcid":false,"given":"William J.","family":"Nahm","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery University of Miami Miller School of Medicine Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4727","authenticated-orcid":false,"given":"Arlene M. Ruiz","family":"de Luzuriaga","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Medicine The University of Chicago Medical Center Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2125-0860","authenticated-orcid":false,"given":"Goranit","family":"Sakunchotpanit","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology NYU Grossman School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiology UMass Chan Medical School Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0473-3054","authenticated-orcid":false,"given":"Krithika","family":"Nayudu","sequence":"additional","affiliation":[{"name":"Medical College of Georgia Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-483X","authenticated-orcid":false,"given":"Ryan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tufts Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7340-4954","authenticated-orcid":false,"given":"Arjun","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod E.","family":"Nambudiri","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston Massachusetts USA"},{"name":"Department of Dermatology Brigham and Women's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15322"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000001312"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18736"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jamadermatol.2019.4194","article-title":"Dermatopathologists' Experience With and Perceptions of Patient Online Access to Pathologic Test Result Reports","volume":"156","author":"Shucard H.","year":"2020","journal-title":"JAMA Dermatology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4195"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/59791"},{"key":"e_1_2_11_8_1","unstructured":"ChatGPT\u2014Release Notes|OpenAI Help Center \u201cChatGPT\u2014Release Notes|OpenAI Help Center \u201d(2025) Openaicom."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010024\u201001029\u20104"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5823"},{"issue":"1","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.35680\/2372-0247.1055","article-title":"The Patient Portal and Abnormal Test Results: An Exploratory Study of Patient Experiences","volume":"2","author":"Giardina T. 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