{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:44:31Z","timestamp":1785735871035,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Poroid hidradenocarcinoma is a rare malignant sweat gland neoplasm. Although primary nodal hidradenoma has been reported, primary nodal poroid hidradenocarcinoma has not been described. We report a case of a 56\u2010year\u2010old man presenting with a nontender 5.5\u2009cm mass within the axillary lymph node, and no identifiable primary cutaneous lesion on clinical examination or imaging. Histopathologic examination of the axillary lymph node dissection revealed involvement of 1 of 42 lymph nodes by a multinodular, solid and cystic neoplasm composed of poroid and cuticular cells with ductal differentiation, consistent with a background poroid hidradenoma. There was an abrupt transition to malignant areas with marked cytologic atypia, nuclear pleomorphism, increased mitotic activity, elevated Ki\u201067 proliferation index and necrosis, supporting the diagnosis of poroid hidradenocarcinoma. Tumor cells were positive for CK5 and CK7. Molecular analysis identified a YAP1::NUTM1 fusion and oncogenic mutations in EGFR exon 20 and FBXW7. At 30\u2009months of follow\u2010up after axillary lymph node dissection and chemoradiation, there was no evidence of disease progression. This case represents the first report of primary nodal poroid hidradenocarcinoma, expanding its clinicopathologic spectrum. Awareness of this entity is important to avoid misdiagnosis as metastatic carcinoma and to prevent potential overtreatment.<\/jats:p>","DOI":"10.1111\/cup.70188","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:47:59Z","timestamp":1785732479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Nodal Poroid Hidradenocarcinoma With\n                    <scp>YAP1<\/scp>\n                    ::\n                    <scp>NUTM1<\/scp>\n                    Fusion: Report of a Rare Case"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4492-200X","authenticated-orcid":false,"given":"Niloufar","family":"Hosseini","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, the Ottawa Hospital University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6931-7527","authenticated-orcid":false,"given":"Omar","family":"Sbeanaty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, the Ottawa Hospital University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Medicine, Anschutz School of Medicine University of Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, the Ottawa Hospital University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Sehdev","sequence":"additional","affiliation":[{"name":"Department of Medicine, the Ottawa Hospital University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brenn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Michigan Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"905","article-title":"Poroid Hidradenoma: A Case Report","volume":"21","author":"Delfino S.","year":"2007","journal-title":"In Vivo"},{"issue":"1","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000531052","article-title":"Poroid Hidradenoma: Case Report and Comprehensive Review of the Literature","volume":"15","author":"Brooks A.","year":"2023","journal-title":"Case Reports in Dermatology"},{"issue":"4","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/modpathol.2009.18","article-title":"Atypical and Malignant Hidradenomas: A Histological and Immunohistochemical Study","volume":"22","author":"Nazarian R. M.","year":"2009","journal-title":"Modern Pathology"},{"issue":"8","key":"e_1_2_9_5_1","first-page":"907","article-title":"Low\u2010Grade Hidradenocarcinomas","volume":"47","author":"Plaza J. A.","year":"2023","journal-title":"American Journal of Surgical Pathology"},{"issue":"6","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1097\/DAD.0000000000001886","article-title":"Three Cases of Clear Cell Hidradenoma With \u201cBenign\u201d Lymph Node Involvement","volume":"43","author":"Gonzalez\u2010Lopez G.","year":"2021","journal-title":"American Journal of Dermatopathology"},{"issue":"8","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/cup.12720","article-title":"Lymph Node Location of a Clear Cell Hidradenoma: Report of a Patient and Review of Literature","volume":"43","author":"Tingaud C.","year":"2016","journal-title":"Journal of Cutaneous Pathology"},{"issue":"12","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1097\/PAS.0b013e3182699363","article-title":"Clear Cell Nodular Hidradenoma Involving the Lymphatic System: A Tumor of Uncertain Malignant Potential or a Novel Example of \u201cMetastasizing\u201d Benign Tumor?","volume":"36","author":"Stefanato C. M.","year":"2012","journal-title":"American Journal of Surgical Pathology"},{"issue":"9","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1172\/JCI126185","article-title":"Recurrent YAP1\u2010MAML2 and YAP1\u2010NUTM1 Fusions in Poroma and Porocarcinoma","volume":"129","author":"Sekine S.","year":"2019","journal-title":"Journal of Clinical Investigation"},{"issue":"9","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/PAS.0000000000001693","article-title":"NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1\u2010NUTM1\u2010Rearranged Cutaneous Poroid Neoplasms","volume":"45","author":"Macagno N.","year":"2021","journal-title":"American Journal of Surgical Pathology"},{"issue":"10","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/cup.14265","article-title":"Molecular Analysis of NUT\u2010Positive Poromas and Porocarcinomas Identifies Novel Break Points of YAP1::NUTM1 Fusions","volume":"49","author":"Snow J. T.","year":"2022","journal-title":"Journal of Cutaneous Pathology"},{"issue":"6","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/gcc.20440","article-title":"Frequent Fusion of the CRTC1 and MAML2 Genes in Clear Cell Variants of Cutaneous Hidradenomas","volume":"46","author":"Winnes M.","year":"2007","journal-title":"Genes, Chromosomes and Cancer"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.humpath.2017.10.004","article-title":"A Novel Fusion Gene CRTC3\u2010MAML2 in Hidradenoma: Histopathological Significance","volume":"70","author":"Kuma Y.","year":"2017","journal-title":"Human Pathology"},{"issue":"3","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/DAD.0b013e3181984f10","article-title":"Cutaneous Hidradenocarcinoma: A Clinicopathological, Immunohistochemical, and Molecular Biologic Study of 14 Cases, Including HER2\/Neu Gene Expression\/Amplification, TP53 Gene Mutation Analysis, and t(11;19) Translocation","volume":"31","author":"Kazakov D. 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B.","year":"2014","journal-title":"International Journal of Dermatology"},{"issue":"8","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/PAS.0b013e3182237985","article-title":"Benign Epithelial Inclusions in Axillary Lymph Nodes: Report of 18 Cases and Review of the Literature","volume":"35","author":"Fellegara G.","year":"2011","journal-title":"American Journal of Surgical Pathology"},{"issue":"5","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.5858\/134.5.781","article-title":"Hidradenocarcinomas: A Brief Review and Future Directions","volume":"134","author":"Gauerke S.","year":"2010","journal-title":"Archives of Pathology and Laboratory Medicine"},{"issue":"6","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine Porocarcinoma (Malignant Eccrine Poroma): A Clinicopathologic Study of 69 Cases","volume":"25","author":"Robson A.","year":"2001","journal-title":"American Journal of Surgical Pathology"},{"issue":"8","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"e47719","DOI":"10.1097\/MD.0000000000047719","article-title":"Epidemiology, Treatment Patterns, and Survival Outcomes of Porocarcinoma: A Population\u2010Based Analysis","volume":"105","author":"Obeidat A.","year":"2026","journal-title":"Medicine"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:48:11Z","timestamp":1785732491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":21,"alternative-id":["10.1111\/cup.70188"],"URL":"https:\/\/doi.org\/10.1111\/cup.70188","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]},"assertion":[{"value":"2026-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70188"}}