{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:51:58Z","timestamp":1785855118940,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Primary cutaneous gamma\u2010delta T\u2010cell lymphoma (PCGD\u2010TCL) is a rare cytotoxic lymphoma with key oncogenic drivers in the\n                    <jats:italic>JAK\/STAT<\/jats:italic>\n                    pathway. Also primarily involving the subcutaneous adipose tissue, subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is more frequently encountered in scenarios of autoimmune disorders. SPTCL shares clinicopathologic overlap with lupus panniculitis. However, the link between autoimmunity and PCGD\u2010TCL is much less established, particularly in the setting of long\u2010standing, immunosuppressed dermatomyositis (DM). We report two cases of PCGD\u2010TCL arising in women with chronic anti\u2010TIF1\u2010\u03b3 DM following years of immunosuppressive therapy. Case 1 is a 47\u2010year\u2010old woman with a 19\u2010year history of DM on azathioprine\/prednisone who developed rapidly progressive, painful subcutaneous nodules. Incisional biopsy confirmed a TCR\u2010delta+, CD8+ cytotoxic T\u2010cell lymphoproliferative disorder (TCLPD) compatible with PCGD\u2010TCL. She achieved complete remission following pralatrexate and subsequent allogeneic hematopoietic stem cell transplant. Case 2 is a 27\u2010year\u2010old woman with DM on mycophenolate\/rituximab who developed subcutaneous nodules with an indolent course and some spontaneous regression. A biopsy revealed a similar panniculitic infiltrate with an atypical TCR\u2010delta+, CD8+ phenotype. Notably, both cases were negative for high\u2010risk\n                    <jats:italic>JAK\/STAT<\/jats:italic>\n                    pathway mutations. These cases identify PCGD\u2010TCLPD\/TCL as a potential complication of chronic, immunosuppressed DM. The shared, atypical CD8+ immunophenotype and absence of canonical driver mutations suggest a distinct pathogenic mechanism possibly linked to long\u2010term immune modulation. Unlike classic PCGD\u2010TCL, which is characterized by an aggressive course and &lt;\u20092\u2010year median survival, the clinical courses in these two cases were variable, with one requiring transplant and the other showing indolent behavior and responsiveness to therapy.\n                  <\/jats:p>","DOI":"10.1111\/cup.70190","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:00:36Z","timestamp":1785852036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Cutaneous Gamma\u2010Delta T\u2010Cell Lymphoma Complicating Long\u2010Standing Immunosuppressed Dermatomyositis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-7102","authenticated-orcid":false,"given":"Bennett","family":"Christie\u2010Nguyen","sequence":"first","affiliation":[{"name":"Department of Pathology UT Health Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-5873","authenticated-orcid":false,"given":"Youn H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-3674","authenticated-orcid":false,"given":"David F.","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Tartar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California\u2014Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7227","authenticated-orcid":false,"given":"Ryanne","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7955-0536","authenticated-orcid":false,"given":"Robert A.","family":"Novoa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Pathology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-2471","authenticated-orcid":false,"given":"Kerri E.","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Pathology Stanford University School of Medicine  Stanford California 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