{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:25:58Z","timestamp":1787538358415,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Epithelioid hemangioma (EH) is a benign vascular tumor that most commonly arises on the skin but may also occur in other anatomical locations, including deep soft tissue, bone, visceral organs, penis, and mucosal sites. A hallmark of EH is overexpression of\n                    <jats:italic>FOS<\/jats:italic>\n                    and\n                    <jats:italic>FOSB<\/jats:italic>\n                    , often resulting from various gene fusions. However, cases in the literature describe diverse mechanisms of\n                    <jats:italic>FOS<\/jats:italic>\n                    \/\n                    <jats:italic>FOSB<\/jats:italic>\n                    expression across EH subtypes, suggesting that these variants may be driven by different molecular pathways. We present a case of an 83\u2010year\u2010old male with multiple well\u2010circumscribed lesions on the right buttock and proximal thigh, demonstrating a multicentric growth pattern with satellitosis and\n                    <jats:italic>FOSB<\/jats:italic>\n                    positivity on immunohistochemistry. To our knowledge, this is one of the few reported cases of multifocal EH demonstrating\n                    <jats:italic>FOSB<\/jats:italic>\n                    positivity, further supporting the emerging view that multifocal EH may represent a true neoplastic process rather than a reactive phenomenon.\n                  <\/jats:p>","DOI":"10.1111\/cup.70202","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:15:55Z","timestamp":1787537755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifocal Epithelioid Hemangioma With\n                    <scp>FOSB<\/scp>\n                    Overexpression"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-6590","authenticated-orcid":false,"given":"Phuong","family":"Daniels","sequence":"first","affiliation":[{"name":"Department of Dermatology Campbell University  Buies Creek North Carolina USA"},{"name":"Department of Dermatology Sampson Regional Medical Center  Clinton North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2961-8978","authenticated-orcid":false,"given":"Aarush","family":"Kumar","sequence":"additional","affiliation":[{"name":"Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Lum","sequence":"additional","affiliation":[{"name":"Michigan State University College of Osteopathic Medicine  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0778-9940","authenticated-orcid":false,"given":"Izabelle","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Campbell University  Buies Creek North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3645-7242","authenticated-orcid":false,"given":"Shannon","family":"DeSilva","sequence":"additional","affiliation":[{"name":"Department of Dermatology Campbell University  Buies Creek North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4870-1802","authenticated-orcid":false,"given":"Jonathan","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Campbell University  Buies Creek North Carolina USA"},{"name":"Department of Dermatology Sampson Regional Medical Center  Clinton North Carolina USA"},{"name":"Atlantic Dermatology  Wilmington North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"McKay","sequence":"additional","affiliation":[{"name":"Emory University  Atlanta Georgia USA"},{"name":"Skinpath Solutions  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.04.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp\u20102023\u2010208931"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.05.008"},{"issue":"11","key":"e_1_2_9_6_1","first-page":"2303","article-title":"Angiosarcoma: A Review of Diagnosis and Current Treatment","volume":"9","author":"Cao J.","year":"2019","journal-title":"American Journal of Cancer 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Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:16:02Z","timestamp":1787537762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":9,"alternative-id":["10.1111\/cup.70202"],"URL":"https:\/\/doi.org\/10.1111\/cup.70202","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,23]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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