{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:08:13Z","timestamp":1788746893455,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102023R1A2C2005650"],"award-info":[{"award-number":["NRF\u20102023R1A2C2005650"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Langerhans cell sarcoma (LCS) is an extremely rare and aggressive neoplasm of histiocytic and dendritic cell lineage. We report a case of cutaneous LCS in a 74\u2010year\u2010old woman, harboring a\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E mutation and demonstrating an aggressive clinical course, including multiple metastatic lesions. During follow\u2010up, the patient was diagnosed with chronic myelomonocytic leukemia and subsequently developed Epstein\u2013Barr virus\u2013positive diffuse large B\u2010cell lymphoma. Additional molecular analyses demonstrated\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600E in the primary LCS but not in the CMML bone marrow or the EBV\u2010positive DLBCL, arguing against a common\n                    <jats:italic>BRAF<\/jats:italic>\n                    \u2010driven clonal origin. Although an earlier shared founder alteration between LCS and CMML cannot be excluded, the subsequent EBV\u2010positive DLBCL most likely developed independently in the setting of CMML\u2010associated immune dysregulation. This case highlights the complexity of multiple hematologic neoplasms and emphasizes the importance of integrated clinicopathologic and molecular evaluation in rare histiocytic neoplasms.\n                  <\/jats:p>","DOI":"10.1111\/cup.70208","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:56:32Z","timestamp":1788746192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Langerhans Cell Sarcoma Harboring\n                    <scp>\n                      <i>BRAF<\/i>\n                      V600E\n                    <\/scp>\n                    Mutation Followed by Chronic Myelomonocytic Leukemia and\n                    <scp>EBV<\/scp>\n                    \u2010Positive Diffuse Large B\u2010Cell Lymphoma"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8367-4023","authenticated-orcid":false,"given":"Seung Hyo","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-5596","authenticated-orcid":false,"given":"Su Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Bum","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4229-5831","authenticated-orcid":false,"given":"Sook Jung","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ctrv.2015.02.011","article-title":"Langerhans Cell Sarcoma: A Systematic Review","volume":"41","author":"Howard J. 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D.","year":"2022","journal-title":"Leukemia"},{"issue":"2","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3960\/jslrt.56.109","article-title":"Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis","volume":"56","author":"Nakamine H.","year":"2016","journal-title":"Journal of Clinical and Experimental Hematopathology"},{"issue":"12","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1007\/s00277-020-04167-3","article-title":"Bone Marrow Coexistence of Chronic Lymphocytic Leukemia and Langerhans Cell Sarcoma","volume":"99","author":"Zanelli M.","year":"2020","journal-title":"Annals of Hematology"},{"issue":"4","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00428-015-1814-8","article-title":"Langerhans Cell Sarcoma Following Marginal Zone Lymphoma: Expanding the Knowledge on Mature B\u2010Cell Plasticity","volume":"467","author":"Ambrosio M. R.","year":"2015","journal-title":"Virchows Archiv"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"Z.Sadeghian K. L.Lyapichev C. L.Fu et\u00a0al. \u201cBRAFPositive Langerhans Cell Sarcoma Arising FromCALRPositive Myeloproliverative Neoplasm: Evidence of a Clonal Progenitor \u201dVirchows Archiv(2025) https:\/\/doi.org\/10.1007\/s00428\u2010025\u201004258\u20104.","DOI":"10.1007\/s00428-025-04258-4"},{"key":"e_1_2_9_12_1","unstructured":"L. I.Butnariu E. 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