{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:07:53Z","timestamp":1789348073057,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50\u2009years. We report an exceptionally rare case of solitary ICH in a 4\u2010year\u2010old boy. A 4\u2010year\u2010old visited our department presenting a solitary asymptomatic bean\u2010sized reddish nodule on upper abdomen for 1\u2009year. Initially thought to be keloid or dermatofibroma, an excisional biopsy was performed. Histopathological examination revealed dense cellular infiltration in the dermis, characterized by medium\u2010sized mononuclear histiocytes displaying abundant glassy eosinophilic cytoplasm and indented or folded nuclei. Immunohistochemistry studies confirmed positivity for S\u2010100 protein and CD1a, coupled with negativity for CD207\/Langerin. Electron microscopy revealed the absence of Birbeck granules, leading to the diagnosis of ICH. With no remarkable findings in laboratory and imaging studies, the patient is undergoing regular follow\u2010up to monitor any potential recurrence or development of related conditions. While most cases of skin\u2010restricted ICH follow an indolent course, recognizing the reported association between ICH and other hematologic neoplasms is crucial. Therefore, awareness of ICH is essential, and in cases of suspicion, a skin biopsy should be performed for an accurate diagnosis.<\/jats:p>","DOI":"10.1111\/cup.70210","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:49:57Z","timestamp":1789346997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Solitary Indeterminate Cell Histiocytosis Presenting as a Reddish Nodule on the Abdomen of a 4\u2010Year\u2010Old Boy: Clinicopathologic Correlation and Electron Microscopy Findings"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6219-1584","authenticated-orcid":false,"given":"Seung\u2010Soo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Lee Seok\u2010Jong Skin Clinic  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weon Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-4795","authenticated-orcid":false,"given":"Dae\u2010Lyong","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Kyungpook National University  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1524-4725.1985.tb01399.x","article-title":"The Indeterminate Cell Proliferative Disorder: Report of a Case Manifesting as an Unusual Cutaneous Histiocytosis","volume":"11","author":"Wood G. 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Collision, Differentiation or Involution?","volume":"26","author":"Solis E.","year":"2004","journal-title":"American Journal of Dermatopathology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1468-3083.2010.03608.x","article-title":"A Case of Multiple Benign Fibrous Histiocytoma With Indeterminate Cells and Eosinophils","volume":"24","author":"Nakai K.","year":"2010","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"453","article-title":"A Case of Solitary Indeterminate Cell Histiocytosis","volume":"30","author":"Amo T.","year":"2003","journal-title":"Journal of Dermatology"},{"issue":"6","key":"e_1_2_10_15_1","first-page":"743","article-title":"Indeterminate Cell Histiocytosis in a Neonate","volume":"29","author":"Toth B.","year":"2012","journal-title":"Pediatric Dermatology"},{"issue":"10","key":"e_1_2_10_16_1","first-page":"910","article-title":"Indeterminate Cell Histiocytosis in Children: A Case Report","volume":"108","author":"Sahuquillo\u2010Torralba M. 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