{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:02:55Z","timestamp":1789714975768,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Malignant perineurioma, also referred to as perineuriomatous malignant peripheral nerve sheath tumor (MPNST), is an exceptionally rare neoplasm with limited clinicopathologic characterization, particularly in children. We report a 12\u2010year\u2010old boy with a 3.0\u2010cm superficial right groin lesion. Histopathologic examination showed a spindle cell neoplasm with fascicular\u2010to\u2010swirling architecture in myxoid to collagenous stroma, moderate cytologic atypia and nuclear variability, mitotic activity, focal necrosis, and admixed inflammation. Epithelial membrane antigen, GLUT1, and claudin\u20101 positivity supported perineurial differentiation, while a broad negative immunohistochemical panel helped exclude potential mimics. Tumor\u2010only sequencing demonstrated 17q loss with focal homozygous NF1 deletion, a\n                    <jats:italic>BRCA2<\/jats:italic>\n                    frameshift, and low tumor mutational burden (3.4 mutations\/Mb); RNA sequencing identified no pathogenic gene fusion. These molecular findings were interpreted as adjunctive rather than independently diagnostic. The tumor extended to the inked specimen edge, and subsequent management and follow\u2010up information was unavailable. To our knowledge, this is the first reported superficial cutaneous malignant perineurioma\/perineuriomatous MPNST in a pediatric patient.\n                  <\/jats:p>","DOI":"10.1111\/cup.70215","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:19:11Z","timestamp":1789712351000},"source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Superficial Malignant Perineurioma\/Perineuriomatous Malignant Peripheral Nerve Sheath Tumor of the Groin With\n                    <scp>NF1<\/scp>\n                    Loss: A Case Report and Focused Review of the Literature"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0124-6868","authenticated-orcid":false,"given":"Arthur William Passos","family":"Raetsch","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital de Cl\u00ednicas Federal University of Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2558-0537","authenticated-orcid":false,"given":"Richard C. K.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Dermatopathology &amp; Oral Pathology Service, Department of Pathology University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-5908","authenticated-orcid":false,"given":"Steven D.","family":"Billings","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cleveland Clinic Lerner College of Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Pincus","sequence":"additional","affiliation":[{"name":"Dermatopathology &amp; Oral Pathology Service, Department of Pathology University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"11","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1097\/00000478-199811000-00007","article-title":"Perineurial Malignant Peripheral Nerve Sheath Tumor (MPNST): A Clinicopathologic, Immunohistochemical, and Ultrastructural Study of Seven Cases","volume":"22","author":"Hirose T.","year":"1998","journal-title":"American Journal of Surgical Pathology"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1440-1827.1999.00815.x","article-title":"Malignant Peripheral Nerve Sheath Tumor With Perineurial Cell Differentiation (Malignant Perineurioma)","volume":"49","author":"Zamecnik M.","year":"1999","journal-title":"Pathology International"},{"issue":"6","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1034\/j.1600-0560.2001.290607.x","article-title":"Malignant Peripheral Nerve Sheath Tumor With Perineurial Differentiation: Malignant Perineurioma","volume":"29","author":"Rosenberg A. E.","year":"2002","journal-title":"Journal of Cutaneous Pathology"},{"issue":"7","key":"e_1_2_8_5_1","first-page":"4503","article-title":"Intraneural Malignant Perineurioma: A Case Report and Review of Literature","volume":"7","author":"Huang Y.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1016\/j.wneu.2021.02.099","article-title":"Sporadic Malignant Perineurioma: A Rare Diagnosis Among Malignant Peripheral Nerve Sheath Tumors","volume":"149","author":"Everson M. C.","year":"2021","journal-title":"World Neurosurgery"},{"issue":"1","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40792-024-01915-9","article-title":"Malignant Perineurioma Derived From the Retroperitoneum With an Aggressive Clinical Course: A Case Report","volume":"10","author":"Kunugitani K.","year":"2024","journal-title":"Surgical Case Reports"},{"issue":"12","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1097\/00000478-200212000-00010","article-title":"Expression of Claudin\u20101, a Recently Described Tight Junction\u2010Associated Protein, Distinguishes Soft Tissue Perineurioma From Potential Mimics","volume":"26","author":"Folpe A. L.","year":"2002","journal-title":"American Journal of Surgical Pathology"},{"issue":"10","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.humpath.2008.03.002","article-title":"GLUT\u20101 Expression in Mesenchymal Tumors: An Immunohistochemical Study of 247 Soft Tissue and Bone Neoplasms","volume":"39","author":"Ahrens W. A.","year":"2008","journal-title":"Human Pathology"},{"issue":"1","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/0973-1482.110381","article-title":"Perineurial Malignant Peripheral Nerve Sheath Tumor in the Setting of Multiple Soft Tissue Perineuriomas: A Rare Presentation of an Uncommon Tumor","volume":"9","author":"Rekhi B.","year":"2013","journal-title":"Journal of Cancer Research and Therapeutics"},{"issue":"11","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1440-1827.2008.02299.x","article-title":"Low\u2010Grade Malignant Soft\u2010Tissue Perineurioma: Interphase Fluorescence in Situ Hybridization","volume":"58","author":"Sato K.","year":"2008","journal-title":"Pathology International"},{"issue":"6","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5414\/NP300423","article-title":"Malignant Perineurioma (Malignant Peripheral Nerve Sheath Tumor With Perineural Differentiation)","volume":"31","author":"Mitchell A.","year":"2012","journal-title":"Clinical Neuropathology"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70215","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:19:13Z","timestamp":1789712353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":11,"alternative-id":["10.1111\/cup.70215"],"URL":"https:\/\/doi.org\/10.1111\/cup.70215","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"cup.70215"}}