{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:02:56Z","timestamp":1789959776643,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Leukemia cutis (LC) refers to cutaneous infiltration by leukemic cells, most often by acute myeloid leukemia (AML) in adults and by lymphoblastic leukemia in children. Although uncommon, LC is a clinically significant manifestation of extramedullary disease and may precede, coincide with, or follow bone marrow involvement. Recognition of AML\u2010associated LC is essential, as it can be diagnostically challenging due to histopathologic overlap with inflammatory dermatoses and other cutaneous hematolymphoid neoplasms. Recent cohort\u2010based studies have systematically characterized AML involving the skin, demonstrating frequent immunophenotypic discordance between cutaneous and marrow blasts and recurrent genetic associations, with important diagnostic and prognostic implications for dermatopathologists. This review provides a practical framework for current and historical nomenclature, the diagnosis of cutaneous AML, and key histopathologic patterns and pitfalls.<\/jats:p>","DOI":"10.1111\/cup.70219","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:31:11Z","timestamp":1789957871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Myeloid Leukemia Involving the Skin"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-764X","authenticated-orcid":false,"given":"Anna Sarah","family":"Erem","sequence":"first","affiliation":[{"name":"Department of Pathology Mass General Brigham, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-8074","authenticated-orcid":false,"given":"Alejandro A.","family":"Gru","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Dermatopathology Columbia University Irving Medical Center\/NewYork\u2010Presbyterian  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15629"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1603102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqae133"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01267-7"},{"issue":"6","key":"e_1_2_11_7_1","first-page":"326","article-title":"Clinical Characterization of Leukemia Cutis Presentation","volume":"104","author":"Haidari W.","year":"2019","journal-title":"Cutis"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.4.614"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.02.015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100352"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890601)63:11<2192::AID-CNCR2820631122>3.0.CO;2-R"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.045047"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-001-0412-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90373-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002917"},{"key":"e_1_2_11_16_1","volume-title":"Haematolymphoid Tumours. WHO Classification of Tumours","author":"Khoury J. D.","year":"2024"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2010.01623.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-00919-6"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493688"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.05.1414"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000491"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(99)70086\u20101"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.129346"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.6092"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2023\u20100132\u2010RA"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013967"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19547"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2023.08.004"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026834"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.3344"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-022-00355-8"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.247569"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000156"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2185091"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12553"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.323"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.146"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0052"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:31:14Z","timestamp":1789957874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":39,"alternative-id":["10.1111\/cup.70219"],"URL":"https:\/\/doi.org\/10.1111\/cup.70219","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70219"}}