{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:01:05Z","timestamp":1790762465637,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The histopathological presentation of psoriasis may vary depending on the timing of the biopsy, prior treatments utilized, and the presence of secondary skin changes. Consequently, dermatopathologists play a pivotal role in ensuring an accurate diagnosis, particularly when the psoriatic histopathology deviates from the classic features. This study aims to compare the prevalence of classic and non\u2010classic histopathologic features of psoriasis between untreated and treated psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a review of 109 biopsies of psoriasis from 2015 to 2021 obtained from a single institution. The cases were reviewed by two independent dermatopathologists who were blinded to the assigned groups (untreated,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200962, and treated,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947). A 20\u2010item histopathologic grading criterion, comprising both classic and non\u2010classic features of psoriasis, was used for assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of both classic (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.274; CI: \u22120.169, 0.593) and non\u2010classic (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.456; CI: \u22120.526, 0.236) histopathologic features of psoriasis did not differ between untreated (classic\u2009=\u200978%, non\u2010classic\u2009=\u200927%) and treated (classic\u2009=\u200976%, non\u2010classic\u2009=\u200929%) groups. A comparison of each histopathologic feature did not vary between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psoriasis is a dynamic condition under the microscope. Classic histopathologic features of psoriasis seem to persist despite treatment. Non\u2010classic features may also occur regardless of the treatment status. Hence, the presence of these features should not preclude the tissue diagnosis of psoriasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.70225","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:16:57Z","timestamp":1790759817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathologic Characterization of Untreated and Treated Psoriasis: A Cross\u2010Sectional Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5736-2024","authenticated-orcid":false,"given":"Terese Monette O.","family":"Aquino","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Surgery, Department of Clinical Epidemiology, Dermatology, and Anatomy University of Santo Tomas  Manila Philippines"},{"name":"Skin and Cancer Foundation Inc.  Pasig City Philippines"},{"name":"Department of Dermatology Quirino Memorial Medical Center  Quezon City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-8771","authenticated-orcid":false,"given":"Mary Grace Anne A.","family":"Calvarido","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ospital ng Maynila Medical Center  Manila Philippines"},{"name":"Philippine Children's Medical Center  Quezon City Philippines"},{"name":"National Kidney and Transplant Institute  Quezon City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine Joy M.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Skin and Cancer Foundation Inc.  Pasig City Philippines"},{"name":"Department of Dermatology Quirino Memorial Medical Center  Quezon City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-3653","authenticated-orcid":false,"given":"Maria Jasmin J.","family":"Jamora","sequence":"additional","affiliation":[{"name":"Skin and Cancer Foundation Inc.  Pasig City Philippines"},{"name":"Department of Dermatology Quirino Memorial Medical Center  Quezon City Philippines"},{"name":"Department of Dermatology Makati Medical Center  Makati Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-8048","authenticated-orcid":false,"given":"Johannes S.","family":"Kern","sequence":"additional","affiliation":[{"name":"Department of Dermatology Alfred Health  Melbourne Australia"},{"name":"Department of Medicine, The School of Translational Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372\u2010197900130\u201000002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13033"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253\u20107176.116232"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010023\u201000809\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2014.963598"},{"key":"e_1_2_11_7_1","unstructured":"J.Love D.Dropmann andR.Selker \u201cJamovi \u201d2022 https:\/\/www.jamovi.org."},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000002094"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s102270000032"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2006.02911.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12498"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247192"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738\u2010081X(95)93819\u2010A"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12492"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20103817"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1973.tb07522.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.28376"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100560.2007.00800.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001711"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417276"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092668"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:16:59Z","timestamp":1790759819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":21,"alternative-id":["10.1111\/cup.70225"],"URL":"https:\/\/doi.org\/10.1111\/cup.70225","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70225"}}