{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:41:24Z","timestamp":1792456884495,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dupilumab inhibits the signaling pathway of interleukins 4 and 13, and can be effective in the management of treatment\u2010refractory atopic dermatitis, with alopecia areata being uncommonly reported as a side effect and only limited to several cases. This is the case of a patient who experienced dupilumab\u2010induced alopecia in treatment for atopic dermatitis and whose histological exam represented findings distinct from classical alopecia areata, telogen effluvium, or underlying psoriatic alopecia, with a potential explanation being inhibition of the Th2 pathway, enhancing a Th1\u2010mediating response by the immune system leading to marked atrophy of the sebaceous glands, which is not reported in alopecia areata. While there is literature describing the potential growth effect of dupilumab in patients with alopecia, there are select reports, along with our case, that suggest its negative effects on the pilosebaceous unit and overall hair growth.<\/jats:p>","DOI":"10.1111\/cup.70242","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:34:42Z","timestamp":1792456482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Alopecia Secondary to Dupilumab in a Patient With Atopic Dermatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4580-040X","authenticated-orcid":false,"given":"Jacob","family":"Myhre","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9204-1429","authenticated-orcid":false,"given":"Jayson","family":"Miedema","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-0530","authenticated-orcid":false,"given":"Rami N.","family":"Al\u2010Rohil","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/17512433.2018.1449642","article-title":"Dupilumab for Treatment of Atopic Dermatitis","volume":"11","author":"Seegr\u00e4ber M.","year":"2018","journal-title":"Expert Review of Clinical Pharmacology"},{"issue":"7","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/1346-8138.16764","article-title":"Dupilumab\u2010Associated Cutaneous Adverse Events Among Adult Patients With Atopic Dermatitis: A Retrospective Study","volume":"50","author":"Napolitano M.","year":"2023","journal-title":"Journal of Dermatology"},{"issue":"24","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa1610020","article-title":"Two Phase 3 Trials of Dupilumab Versus Placebo in Atopic Dermatitis","volume":"375","author":"Simpson E.","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","DOI":"10.5826\/dpc.1404a270","article-title":"Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of the Literature","volume":"14","author":"Starace M.","year":"2024","journal-title":"Dermatology Practical & Conceptual"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jdcr.2018.10.010","article-title":"Drug\u2010Induced Alopecia After Dupilumab Therapy","volume":"5","author":"Flanagan K.","year":"2018","journal-title":"JAAD Case Reports"},{"issue":"12","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.3390\/cells10123397","article-title":"The Role of Serum Th1, Th2, and Th17 Cytokines in Patients With Alopecia Areata: Clinical Implications","volume":"10","author":"Wa\u015bkiel\u2010Burnat A.","year":"2021","journal-title":"Cells"},{"issue":"2","key":"e_1_2_8_8_1","article-title":"Improvement of Atopic Dermatitis and Alopecia Universalis With Dupilumab","volume":"14","author":"Alotaibi L.","year":"2021","journal-title":"Dermatology Reports"},{"issue":"2","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jaci.2023.11.923","article-title":"Thymic Stromal Lymphopoietin Induces IL\u20104\/IL\u201013 From T Cells to Promote Sebum Secretion and Adipose Loss","volume":"154","author":"Choa R.","year":"2024","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.jid.2016.05.113","article-title":"Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?","volume":"136","author":"Ritti\u00e9 L.","year":"2016","journal-title":"Journal of Investigative Dermatology"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cup.70242","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.70242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:34:44Z","timestamp":1792456484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.70242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":9,"alternative-id":["10.1111\/cup.70242"],"URL":"https:\/\/doi.org\/10.1111\/cup.70242","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cup.70242"}}