{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:48:48Z","timestamp":1778028528728,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patients diagnosed with bladder carcinoma <jats:italic>in\u00a0situ<\/jats:italic> (<jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>) and treated with intravesical Bacillus Calmette\u2013Guerin (<jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>) often undergo post\u2010induction random bladder biopsies to assess treatment response. We sought to determine the correlation between post\u2010induction urinary cytology\/cystoscopy and histopathological findings obtained by random bladder biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were treated with <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> between 2006 and 2010 for <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content>, had surveillance cystoscopy and cytology, and subsequently underwent random bladder biopsies were selected for analysis. Patients with a history of or concomitant urothelial cell carcinoma (<jats:styled-content style=\"fixed-case\">UCC<\/jats:styled-content>) stage T1 or higher were excluded. Cystoscopic finings were characterized as follows: <jats:italic>negative<\/jats:italic> \u2013 no mucosal erythema, raised lesions or papillary tumours; <jats:italic>suspicious<\/jats:italic> \u2013 mucosal erythema, but no raised lesions or papillary tumours; and <jats:italic>positive<\/jats:italic> \u2013 sessile or papillary tumours. The accuracy of cytology in predicting the results of subsequent random bladder biopsies was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 21 patients included, surveillance cystoscopy findings were characterized as <jats:italic>negative<\/jats:italic> in nine, <jats:italic>suspicious<\/jats:italic> in seven and <jats:italic>positive<\/jats:italic> in five. Of 16 patients with <jats:italic>negative\/suspicious<\/jats:italic> cystoscopy, 13 had agreement between cytology and biopsy, nine of whom were negative and four positive. Three of 16 patients had positive cytology, but negative biopsies; on further investigation of these three, one had <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content> and two subsequent <jats:styled-content style=\"fixed-case\">UCC<\/jats:styled-content>. In the <jats:italic>positive<\/jats:italic> cystoscopy group, four of five patients had agreement between cytology and biopsy, two of whom were negative and two positive. One of the five patients had negative cytology, but a positive biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest foregoing random bladder biopsies in patients with negative urine cytology and no evidence of intravesical recurrence on cystoscopy following an induction course of <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">CIS<\/jats:styled-content> of the urinary bladder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12064","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T04:10:52Z","timestamp":1364962252000},"page":"108-111","source":"Crossref","is-referenced-by-count":5,"title":["Assessing treatment response after induction <scp>B<\/scp>acillus <scp>C<\/scp>almette\u2013<scp>G<\/scp>uerin for carcinoma <i>in\u00a0situ<\/i> of the urinary bladder: can post\u2010induction random bladder biopsies be avoided?"],"prefix":"10.1111","volume":"25","author":[{"given":"P. J.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Urology UT Southwestern Medical School Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Lotan","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical School Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. V.","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical School Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. I.","family":"Sagalowsky","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical School Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Margulis","sequence":"additional","affiliation":[{"name":"Department of Urology UT Southwestern Medical School Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Bladder Cancer Clinical Guideline Update Panel.American Urological Association [Internet] Guideline for the management of nonmuscle invasive bladder cancer: (stages Ta T1 and Tis).2007. Available at:http:\/\/www.auanet.org\/content\/clinical-practice-guidelines\/clinical-guidelines.cfm?sub=bc[Accessed 15 April 2012]."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-88441-7"},{"key":"e_1_2_5_5_1","first-page":"499","article-title":"Carcinoma in situ","volume":"19","author":"Lamm DL","year":"1992","journal-title":"Urol Clin North Am"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.12.011"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.032"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.06.135"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000062605.92268.c6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.11.033"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365590903419020"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00157-X"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.1998.tb00229.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.12.004"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10210.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.04.023"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(97)00206-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61899-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)67054-X"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12064","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:10:54Z","timestamp":1696306254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/cyt.12064"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12064","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,2]]}}}