{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:09:18Z","timestamp":1697432958548},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify whether recurrences were picked up by cytology alone after radical vaginal trachelectomy and to determine the false\u2010positive rate of abnormal cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective collection of patients from the cancer registry since radical vaginal trachelectomy was first performed in Bristol in 1999. All cytology results were collated and re\u2010reviewed by a senior consultant cellular pathologist at the cytopathology centre in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outhmead <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ristol. Cytology results and pathology and survival data are discussed, and any downgrading or upgrading of reports is reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen women were identified and 80 isthmic cytology samples were reviewed. Only one recurrence has occurred. Lower uterine segment sampling was apparent in 25 samples and other endometrial cells in 21 samples: thus 58% showed endometrial cell sampling. Odd metaplastic cells from the newly formed transformation zone were found in 25 samples (31%). Fifteen (19%) showed significant inflammation, two with actinomyces. After cytology review, seven of 80 reports were changed: two between negative and inadequate, two borderline changes in endocervical cells and one mild dyskaryosis were downgraded to negative, and two cases reported as ?glandular neoplasia were changed to squamous cell carcinoma and negative, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytology reporting may be challenging after trachelectomy. Cytology in our series did not add to the diagnosis of recurrence in the one case in which it occurred. We propose a pragmatic follow\u2010up regime, and discuss the importance of the centralization of cytology reporting in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12066","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T08:06:51Z","timestamp":1372320411000},"page":"95-100","source":"Crossref","is-referenced-by-count":8,"title":["The role of cytological follow\u2010up after radical vaginal trachelectomy for early\u2010stage cervical cancer"],"prefix":"10.1111","volume":"25","author":[{"given":"K.","family":"Edey","sequence":"first","affiliation":[{"name":"Department of Gynaecology St Michael's Hospital Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Denton","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Southmead Hospital Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Department of Gynaecology St Michael's Hospital Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00671074"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3552(05)80392-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.07.040"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.05.032"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.04.027"},{"key":"e_1_2_5_7_1","first-page":"705","article-title":"Atypical glandular cells in cervical smears from women who have undergone cone biopsy. A potential diagnostic pitfall","volume":"37","author":"Lee KR","year":"1993","journal-title":"Acta Cytol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.4.511"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23256"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2003.00122.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21059"},{"key":"e_1_2_5_12_1","first-page":"656","article-title":"Limited value of vaginal cytology in detecting recurrent disease after radical hysterectomy for early stage cervical carcinoma","volume":"7","author":"Injumpa N","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_5_13_1","first-page":"106","article-title":"A comparison of symptomatology, physical examination, and vaginal cytology in the detection of recurrent cervical carcinoma after radical hysterectomy","volume":"76","author":"Soisson AP","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00162.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.08.135"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:11:24Z","timestamp":1696306284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/cyt.12066"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12066","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]}}}