{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:11:32Z","timestamp":1773274292573,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T00:00:00Z","timestamp":1378080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this study, we investigated the efficacy of the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ethesda system (<jats:styled-content style=\"fixed-case\">TBS<\/jats:styled-content>) for reporting thyroid cytopathology in determining the risk of malignancy for indeterminate cases. These cases comprised atypia or follicular lesion of undetermined significance (<jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content>), follicular neoplasia or suspicious for follicular neoplasia (<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SFN<\/jats:styled-content>) and suspicious for malignancy (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>) categories. <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content> cases were further subcategorized according to their patterns, and the malignancy rate for each subcategory was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 6310 thyroid fine needle aspiration (<jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content>) cases were analysed and 655 indeterminate cases were enrolled in the study. <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content> cases were further subcategorized into four patterns as follows: papillary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) pattern, microfollicle pattern, atypical cell pattern and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\u00fcrthle cell pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Malignancy rates for <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SFN<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> were 18.9%, 45.7% and 71%, respectively. Malignancy rates for <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content> subcategories were as follows: <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> pattern, 28%; microfollicle pattern, 6.9%; atypical cell pattern, 22.2%; and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\u00fcrthle cell pattern, 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ethesda system categorizes thyroid <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content>s with increasing risk of malignancy as advocated. However, our findings suggest that the risk of malignancy for <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content> might be higher than estimated. Particularly, <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content> cases with focal features suggestive of <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> seem to be associated with a much higher risk of malignancy than other patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12091","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T04:55:01Z","timestamp":1378184101000},"page":"177-184","source":"Crossref","is-referenced-by-count":45,"title":["The <scp>B<\/scp>ethesda system for reporting thyroid cytopathology: an institutional experience of the outcome of indeterminate categories"],"prefix":"10.1111","volume":"25","author":[{"given":"S.","family":"\u00d6nder","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Firat","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.565"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010163"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10043"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334218"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21185"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333227"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20091"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333232"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20154"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/8VL9-ECXY-NVMX-2RQF"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690000800304"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0798-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203208"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21292"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.052"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2601-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.05.038"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20132"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20440"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0014"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325920"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333274"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:59:47Z","timestamp":1696363187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,2]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/cyt.12091"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12091","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,2]]}}}