{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:11:54Z","timestamp":1756311114436},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To review cytomorphological criteria and clinicopathological findings in combination with ancillary tests for the specific diagnosis of pulmonary marginal zone lymphoma (<jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content>) in fine needle aspiration (<jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content>) specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of pulmonary <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> diagnosed using cytological specimens from 2005 to 2012 were retrieved and reviewed by three cytopathologists. Results of immunophenotypic analysis, interphase fluorescence <jats:italic>in\u00a0situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) and molecular assays were collated, together with clinical information and imaging data. Concurrent surgical biopsies were also retrieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen lung <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content> specimens were identified. The smears consisted predominantly of small centrocyte\u2010like cells. Marked plasma cell differentiation was evident in 11 cases. All cases with slides available showed tissue fragments with lymphoid tangles (<jats:styled-content style=\"fixed-case\">TFLT<\/jats:styled-content>s). Multinucleated giant cells were present in nine cases, two of which showed granulomas. Immunophenotyping confirmed <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell clonality in all cases. B\u2010cell clonality was detected by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) in two samples. <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> identified <jats:italic><jats:styled-content style=\"fixed-case\">MALT<\/jats:styled-content>1<\/jats:italic> translocation in four of 10 cases tested and trisomy 3 in three of four cases. Concurrent surgical biopsies were diagnosed independently as <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> in seven cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytology smears from lung <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content> samples consisting of small lymphoid cells with a relative abundance of plasma cells or plasmacytoid cells and large <jats:styled-content style=\"fixed-case\">TFLT<\/jats:styled-content>s should prompt immunophenotyping and other ancillary studies, even if multinucleated giant cells and poorly formed granulomas are also identified. Specific diagnosis of pulmonary <jats:styled-content style=\"fixed-case\">MZL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content> samples can be rendered on the basis of morphological features coupled with the demonstration of B\u2010cell clonality by immunophenotyping or <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and cytogenetic abnormalities by <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12119","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T02:09:24Z","timestamp":1385086164000},"page":"250-258","source":"Crossref","is-referenced-by-count":10,"title":["Cytomorphological and clinicopathological spectrum of pulmonary marginal zone lymphoma: the utility of immunophenotyping, <scp>PCR<\/scp> and <scp>FISH<\/scp> studies"],"prefix":"10.1111","volume":"25","author":[{"given":"H. M.","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. R.","family":"Geddie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Boerner","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rogalla","sequence":"additional","affiliation":[{"name":"Joint Department of Medical Imaging University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"da Cunha Santos","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"214","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Isaacson PG","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00039309"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.1.201"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80074-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.11.920"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5337(02)00083-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00831.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199904)20:4<190::AID-DC2>3.0.CO;2-E"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.6.825"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.5.579"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-1673-SMDIEM"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.4.488"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20877"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11509"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.02.005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20166"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-8592(96)70017-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20075"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20098"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0068"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.071423"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200108000-00003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00801.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11903"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20070"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21203"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63908-9"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300000491"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12119","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:58:00Z","timestamp":1696334280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cyt.12119"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12119","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}