{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:08:53Z","timestamp":1769558933333,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Endometrial carcinoma (<jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>) is the leading female genital tract malignancy in industrialized countries. It will become an important public health problem in the coming years in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and Europe, where its incidence is increasing, and next\u2010generation interventions should include periodical screening in high\u2010risk women. In this review, we discuss the importance to gynaecologists of detecting women at high risk and offering an adequate screening programme. Screening for <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content> is particularly challenging and there is currently no proven programme for the surveillance of women estimated to be at an increased risk of developing this form of cancer. The data in the literature, including this and previous issues of <jats:italic>Cytopathology<\/jats:italic>, and personal experience suggest that endometrial liquid\u2010based cytology (<jats:styled-content style=\"fixed-case\">LBC<\/jats:styled-content>) might play an essential role in a screening policy for <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LBC<\/jats:styled-content> may enable practitioners to reduce age\u2010adjusted mortality for women at high risk for <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cyt.12131","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T03:53:24Z","timestamp":1390881204000},"page":"71-77","source":"Crossref","is-referenced-by-count":17,"title":["Endometrial carcinoma in high\u2010risk populations: is it time to consider a screening policy?"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Fambrini","sequence":"first","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sisti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cioni","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Turrini","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Taddei","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Guaschino","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Clinical and Experimental Sciences University of Florence Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67063-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182605bf1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.1.97"},{"key":"e_1_2_9_5_1","unstructured":"Cancer Research UK. Available at:www.cancerresearchuk.org\/cancerinfo\/cancerstats\/types\/uterus\/incidence\/#geog."},{"key":"e_1_2_9_6_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132008","author":"Howlader N","year":"2011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.2.67"},{"key":"e_1_2_9_8_1","first-page":"913","article-title":"Annual report on cervical, endometrial, and ovarian cancer","volume":"61","author":"Oncology Committee","year":"2007","journal-title":"Acta Obstet Gynaecol Jpn"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.05.001"},{"key":"e_1_2_9_10_1","first-page":"1531","article-title":"Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review","volume":"11","author":"Kaaks R","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.13.1739"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(06)60031-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.08.075"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e3e7e8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001015)89:8<1765::AID-CNCR17>3.0.CO;2-F"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)90744-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90084-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2003.02120.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1247"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.1.43"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.57.2.90"},{"key":"e_1_2_9_23_1","first-page":"43","article-title":"Uterine body cancer mass screening at Tokai University Hospital","volume":"29","author":"Nagase E","year":"2004","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000296488.85807.b3"},{"key":"e_1_2_9_25_1","first-page":"882","article-title":"Thin\u2010layer cytology and histopathology in the evaluation of abnormal uterine bleeding","volume":"48","author":"Garcia F","year":"2003","journal-title":"J Reprod Med"},{"key":"e_1_2_9_26_1","first-page":"179","article-title":"Thin layer method in endometrial cytology","volume":"95","author":"Buccoliero AM","year":"2003","journal-title":"Pathologica"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00224.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00463.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23636"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20655"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00757.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01019.x"},{"key":"e_1_2_9_33_1","first-page":"621","article-title":"Reliability of outpatient endometrial brush cytology vs biopsy in postmenopausal symptomatic women","volume":"31","author":"Mossa B","year":"2010","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000113047"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12013"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12027"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1997.4699"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02677-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610400008016"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70268-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00581.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336258"},{"key":"e_1_2_9_43_1","first-page":"812","article-title":"Endometrial metaplasia associated with endometrial carcinoma","volume":"80","author":"Kaku T","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199310000-00003"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12055"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0947-3"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.7173"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23495"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318159b88e"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.012"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.044347"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12095"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22869"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326722"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12131","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:11:56Z","timestamp":1696306316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,27]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/cyt.12131"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12131","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,27]]}}}