{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:21Z","timestamp":1790050701499,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objective<\/jats:title>\n \n Oral cavity non\u2010\n H<\/jats:styled-content>\n odgkin lymphoma (\n OCL<\/jats:styled-content>\n ) is a rare condition that may be clinically and radiologically indistinguishable from other pathologies of the mouth. A complete excision or adequate biopsy of the\n OCL<\/jats:styled-content>\n may be difficult. Fine needle aspiration (\n FNA<\/jats:styled-content>\n ) cytology has been successfully utilized in the pre\u2010operative diagnosis of oral masses and in lymphoma involving other anatomical areas. Our experience with\n FNA<\/jats:styled-content>\n pre\u2010operative cytological diagnosis of 16\n OCL<\/jats:styled-content>\n s is reported herein.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The results of\n FNA<\/jats:styled-content>\n cytology on 16 consecutive lymphoproliferative lesions of the oral cavity collected over an 8\u2010year period in three institutions were retrieved. Sampled lesions were submucosal masses of different sizes bulging into the oral cavity. Rapid on\u2010site evaluation (\n ROSE<\/jats:styled-content>\n ) and routine cytological staining were performed. Immunocytochemistry (\n ICC<\/jats:styled-content>\n ), flow cytometry (\n FC<\/jats:styled-content>\n ) and polymerase chain reaction (\n PCR<\/jats:styled-content>\n ) of the\n IGH<\/jats:styled-content>\n (immunoglobulin heavy) locus were performed on additional passes according to\n ROSE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fourteen\n OCL<\/jats:styled-content>\n s, one myeloma and one florid reactive lymphoid hyperplasia (\n FRLH<\/jats:styled-content>\n ) were diagnosed by\n FNA<\/jats:styled-content>\n .\n OCL<\/jats:styled-content>\n s were diagnosed as large\n B<\/jats:styled-content>\n \u2010cell (eight cases) and small\n B<\/jats:styled-content>\n \u2010cell (six cases) lymphomas. Histology revealed eight diffuse large\n B<\/jats:styled-content>\n \u2010cell lymphomas (\n DLBCL<\/jats:styled-content>\n ), four lymphomas of mucosa\u2010associated lymphoid tissue (\n MALT<\/jats:styled-content>\n ), two follicular lymphomas and one\n FRLH<\/jats:styled-content>\n ; no false\u2010negative or false\u2010positive results were diagnosed, but accurate subclassification was obtained in four cases only.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n FNA<\/jats:styled-content>\n diagnosis of\n OCL<\/jats:styled-content>\n s may be hampered by the rare incidence, anatomical context and difficulties in obtaining a sufficient amount of cells. Ancillary techniques should be used according to\n ROSE<\/jats:styled-content>\n ; a pre\u2010operative\n FNA<\/jats:styled-content>\n cytology diagnosis can avoid unnecessary extensive surgery and speed up the institution of therapeutic procedures.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cyt.12132","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T03:34:42Z","timestamp":1391744082000},"page":"241-249","source":"Crossref","is-referenced-by-count":30,"title":["Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity"],"prefix":"10.1111","volume":"25","author":[{"given":"I.","family":"Cozzolino","sequence":"first","affiliation":[{"name":"Department of Public Health University of Naples \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vigliar","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Todaro","sequence":"additional","affiliation":[{"name":"Department of Human Pathology \u2018Gaetano Barresi\u2019 University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Peluso","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Biotechnologies University of Naples \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Picardi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Biotechnologies University of Naples \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. V.","family":"Sosa Fernandez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Mignogna","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatologic Sciences University of Naples \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tuccari","sequence":"additional","affiliation":[{"name":"Department of Human Pathology \u2018Gaetano Barresi\u2019 University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Selleri","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Zeppa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.116062"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.02.019"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199908000-00009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.06.188"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.106581"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.83461"},{"key":"e_1_2_5_8_1","first-page":"683","article-title":"Intraoral and transoral fine needle aspiration. 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