{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:38:30Z","timestamp":1776170310898,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Large non\u2010functioning parathyroid cysts represent a rare entity with a benign clinical course. They may be misdiagnosed as thyroid cystic neoplasms on fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>), resulting in inappropriate surgical treatment. We evaluated our institutional experience in the diagnosis of large parathyroid cystic lesions underlining all the differential diagnoses and pitfalls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the period between 1998 and 2012, we reported the cytology of eight large (&gt;2.5\u00a0cm) parathyroid cystic lesions (all female patients) with histological control. The aspirations were performed with a 25\u2010gauge needle with ultrasonographic guidance. The aspirated material was processed with liquid\u2010based cytology (<jats:styled-content style=\"fixed-case\">LBC<\/jats:styled-content>). All the patients had normal serum parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) and calcium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cytological samples showed a fluid watery component without colloid and few or absent epithelial cells. The resulting negativity for thyroglobulin and positivity for <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>, carried out on the cystic fluids, suggested parathyroid lesions rather than either thyroid cystic lesions (including follicular thyroid neoplasm) or cystic malignant lesions. All the patients underwent surgery without complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the best of our knowledge, this is one of the largest series with cytohistological evaluation of large parathyroid cysts. The incidence of large parathyroid cysts remains controversial as most patients are asymptomatic. <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> may be performed with conclusive results in the majority of cystic cases. The detection of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and calcium on the cystic liquid is likely to achieve a correct cytological diagnosis, allowing adequate treatment and ruling out a more frequent thyroid lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12153","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T04:30:40Z","timestamp":1399869040000},"page":"114-121","source":"Crossref","is-referenced-by-count":19,"title":["Large non\u2010functioning parathyroid cysts: our institutional experience of a rare entity and a possible pitfall in thyroid cytology"],"prefix":"10.1111","volume":"26","author":[{"given":"E. D.","family":"Rossi","sequence":"first","affiliation":[{"name":"Division of Anatomic Pathology and Histology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Revelli","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Giustozzi","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Straccia","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stigliano","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fadda","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology and Histology Universit\u00e0 Cattolica del Sacro Cuore \u201cAgostino Gemelli\u201d School of Medicine Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"151","article-title":"Parathyroid cysts; report of five cases","volume":"34","author":"Crile GJ","year":"1953","journal-title":"Surgery"},{"key":"e_1_2_6_3_1","first-page":"190","article-title":"Exstirpation von drie cystischen Nebenschilddrusenlappen [Extirpation of three parathyroid lobules]","volume":"22","author":"Goris D","year":"1906","journal-title":"Int Zentral Laryngol Rhinol Wissensch"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.5.592"},{"key":"e_1_2_6_5_1","first-page":"118","article-title":"Parathyroid cyst: an uncommon cause of a palpable neck mass and hypercalcemia","volume":"170","author":"Pinney SP","year":"1999","journal-title":"West J Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30085-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20661"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001904923"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90073-9"},{"key":"e_1_2_6_11_1","first-page":"851","article-title":"Functional parathyroid cyst: a rare cause of malignant hypercalcemia with primary hyperparathyroidism\u2014a case report and review of the literature","volume":"5","author":"Khan A","year":"2012","journal-title":"Case Rep Med"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326400"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-60-713-439"},{"key":"e_1_2_6_14_1","volume-title":"Guidelines for the Management of Thyroid Cancer","author":"British Thyroid Association","year":"2007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.975"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0181"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21026"},{"key":"e_1_2_6_18_1","first-page":"439","article-title":"Luber parathyreoideale Halszysten","volume":"64","author":"Nylander PE","year":"1929","journal-title":"Acta Chir Scand"},{"key":"e_1_2_6_19_1","first-page":"1","article-title":"The pathology of the parathyroid gland in hyperparathyroidism: a study of 25 cases","volume":"11","author":"Castleman B","year":"1935","journal-title":"Am J Pathol"},{"key":"e_1_2_6_20_1","first-page":"476","article-title":"Parathyroid cyst and cystic degeneration of parathyroid adenoma","volume":"88","author":"Rogers LA","year":"1969","journal-title":"Arch Pathol"},{"key":"e_1_2_6_21_1","first-page":"287","article-title":"The parathyroid glands. II. Their pathology in man.","volume":"49","author":"Forsyth D","year":"1980","journal-title":"Q J Med"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2008.531"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345727"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04037.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329029"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-6-793"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.6.776"},{"key":"e_1_2_6_28_1","first-page":"939","article-title":"Diagnosis of parathyroid cysts: value of parathyroid hormone level in puncture fluid","volume":"29","author":"Nozeran S","year":"2000","journal-title":"Presse Med"},{"key":"e_1_2_6_29_1","first-page":"447","article-title":"Fine needle aspiration cytology of cystic parathyroid lesions. A cytomorphologic overlap with cystic lesions of the thyroid","volume":"35","author":"Layfield LJ","year":"1991","journal-title":"Acta Cytol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2009.00659.x"},{"key":"e_1_2_6_31_1","first-page":"333","article-title":"The role of fine\u2010needle aspiration performed with liquid based cytology in the surgical management of thyroid lesions","volume":"24","author":"Ardito G","year":"2010","journal-title":"In Vivo"},{"key":"e_1_2_6_32_1","first-page":"710","article-title":"The Papanicolaou Society of Cytopathology Task Force on Standards of Practice. Guidelines of the Papanicolaou Society of Cytopathology for the examination of fine needle aspiration specimens from thyroid nodules","volume":"9","author":"Suen KC","year":"1996","journal-title":"Mod Pathol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1385\/EP:11:4:373"},{"key":"e_1_2_6_35_1","first-page":"420","article-title":"Needle aspiration of nonfunctioning parathyroid cysts","volume":"56","author":"Prinz RA","year":"1990","journal-title":"Am Surg"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0748-8"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.10.009"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1372"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12153","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:20:34Z","timestamp":1695547234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/cyt.12153"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12153","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}