{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:11:04Z","timestamp":1762899064126,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G9700808"],"award-info":[{"award-number":["G9700808"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Worldwide, each year, large numbers of women are referred for colposcopy following low\u2010grade abnormal cervical cytology. Many have no visible abnormality on examination. The risk of cervical intra\u2010epithelial neoplasia grade 2\/3 (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\/3) in these women is low. It is unknown whether, for women, a normal colposcopy resolves the anxiety which often follows the receipt of an abnormal cytology result. We investigated the prevalence of adverse psychological outcomes over 30\u00a0months following a normal colposcopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study was nested within the <jats:styled-content style=\"fixed-case\">UK TOMBOLA<\/jats:styled-content> randomized controlled trial. Women aged 20\u201359\u00a0years, with recent low\u2010grade cytology, who had a satisfactory colposcopy examination and normal transformation zone, completed the Hospital Anxiety and Depression Scale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>) and Process Outcome Specific Measure (<jats:styled-content style=\"fixed-case\">POSM<\/jats:styled-content>) at recruitment and during follow\u2010up (12, 18, 24 and 30\u00a0months post\u2010recruitment). Outcomes included percentages reporting significant anxiety (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content> anxiety subscale score \u226511), significant depression (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content> depression subscale score \u22658) or worries about the result of the next cytology test, cervical cancer, having sex, future fertility and general health at each time point (point prevalence) and during follow\u2010up (cumulative prevalence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 727 women. All psychological measures (except depression) had high prevalence at recruitment, falling substantially by 12\u00a0months. During follow\u2010up, the cumulative prevalence of significant anxiety was 27% and significant depression was 21%. The most frequently reported worry was that the next cytology test would be abnormal (cumulative prevalence of 71%; point prevalence of \u226550% at 12 and 18\u00a0months). The cumulative prevalence values of worries about cervical cancer, having sex and future fertility were 33%, 20% and 16%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For some women who have low\u2010grade cytology, a normal colposcopy does not appear to provide psychological reassurance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12173","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T09:45:30Z","timestamp":1407318330000},"page":"178-187","source":"Crossref","is-referenced-by-count":15,"title":["A normal colposcopy examination fails to provide psychological reassurance for women who have had low\u2010grade abnormal cervical cytology"],"prefix":"10.1111","volume":"26","author":[{"given":"S. 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G.","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Hull Kingston upon Hull UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. K.","family":"Whynes","sequence":"additional","affiliation":[{"name":"School of Economics University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Cruickshank","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology University of Aberdeen Foresterhill Aberdeen UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the TOMBOLA Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27650"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.053"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182883a34"},{"key":"e_1_2_8_5_1","unstructured":"NHS National Statistics. Health and Social Care Information Centre. 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