{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:20:01Z","timestamp":1761744001946},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>\n<jats:bold>Background<\/jats:bold>\n<\/jats:title><jats:p>Fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) of axillary lymphadenopathy is a helpful tool in the pre\u2010operative diagnosis of breast cancer patients with axillary lymphadenopathy. To date, no published meta\u2010analysis or systematic review has been performed to assess its overall value. We therefore conducted a meta\u2010analysis to establish the overall diagnostic value of <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> for axillary lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Methods<\/jats:bold>\n<\/jats:title><jats:p>After a review and quality assessment of 31 studies, published either in Chinese or English, the sensitivity, specificity and other measurements of accuracy of <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> of axillary lymphadenopathy were pooled using random\u2010effects models. A summary of the receiver\u2010operating characteristic curves was used to summarize overall accuracy.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Results<\/jats:bold>\n<\/jats:title><jats:p>We provided the following estimated values for <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> in the diagnosis of axillary lymph node metastasis: sensitivity, 0.63 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 0.61\u20130.65]; specificity, 0.99 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.99\u20130.99); positive likelihood ratio, 26.52 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 18.42\u201338.18); negative likelihood ratio, 0.34 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.29\u20130.40); diagnostic odds ratio, 76.73 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 51.98\u2013113.28).<\/jats:p><\/jats:sec><jats:sec><jats:title>\n<jats:bold>Conclusions<\/jats:bold>\n<\/jats:title><jats:p>FNAC has adequate sensitivity and high specificity in the diagnosis of axillary lymph node metastasis. A positive axillary <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content> result could potentially alter disease management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12224","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T11:57:16Z","timestamp":1418299036000},"page":"59-69","source":"Crossref","is-referenced-by-count":16,"title":["Axillary fine needle aspiration cytology is a sensitive and highly specific technique for the detection of axillary lymph node metastasis: a meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"27","author":[{"given":"Y.\u2010H.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Guangxi Cancer Hospital &amp; Affiliated Cancer Hospital of Guangxi Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.\u2010G.","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Guangxi Cancer 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