{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:59:18Z","timestamp":1789156758742,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study looks at the importance of large loop excision of the transformation zone (<jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>) excision margins and residual cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>) in women undertaking high\u2010risk human papillomavirus (hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) test of cure (<jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study with interval analysis performed June 2007 and June 2012 on all women undertaking treatment for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> and subsequent hr<jats:styled-content style=\"fixed-case\">HPV TOC<\/jats:styled-content> 6 months post <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final analysis group comprised 2093 women treated by <jats:styled-content style=\"fixed-case\">LLETZ<\/jats:styled-content> (1396 completely excised; 697 incompletely excised). 298 out of 1794 women (13%) were hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive at <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content>. Thirty\u2010six women who failed <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content> and attended colposcopy had residual <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>. No statistically significant difference existed between the completely and incompletely excised groups with regards to the detection of residual <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> at 6 months post\u2010treatment. There was no correlation of margins of excision with hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> status at <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content>. The overall cure rate at <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content> was 98%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content> pathways recommend subsequent follow\u2010up in primary care. This study identified no safety issues with <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content> pathways. We can no longer assess histological failure rates at 12 months; we, therefore, recommend that this measure of treatment failure be redefined for post <jats:styled-content style=\"fixed-case\">TOC<\/jats:styled-content> women. It seems time to question the benefits of routine excision margins reporting, in the absence of invasion, for treated <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>. Future reporting needs to be reconsidered by the Royal College of Pathologists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12260","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T07:03:30Z","timestamp":1443510210000},"page":"210-217","source":"Crossref","is-referenced-by-count":11,"title":["Does <scp>LLETZ<\/scp> excision margin status predict residual disease in women who have undergone post\u2010treatment cervical cytology and high\u2010risk human papillomavirus testing?"],"prefix":"10.1111","volume":"27","author":[{"given":"J. E.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology\/Jessop Wing Colposcopy Unit Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ravenscroft","sequence":"additional","affiliation":[{"name":"Doncaster and Bassetlaw NHS Foundation Trust Doncaster UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Cytology Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Crossley","sequence":"additional","affiliation":[{"name":"Department of Cytology Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dudding","sequence":"additional","affiliation":[{"name":"Department of Cytology Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Cytology Sheffield Hospitals NHS Trust Sheffield UK"},{"name":"Department of Histopathology &amp; Cytology, Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Tidy","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology\/Jessop Wing Colposcopy Unit Sheffield Hospitals NHS Trust Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"HPV testing.Introduction of HPV testing in England. BSCCP.Available at URL<http:\/\/www.bsccp.org.uk\/index.asp?PageID=166>. 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