{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:09:35Z","timestamp":1763968175118},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T00:00:00Z","timestamp":1449878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Poorly differentiated thyroid carcinoma (<jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content>) is an uncommon thyroid malignancy with biological behaviour intermediate between well\u2010differentiated and undifferentiated thyroid carcinoma. The cytological diagnosis of <jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content> is often difficult as a result of a lack of well\u2010established cytomorphological features and a considerable degree of morphological overlap with other commoner thyroid neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the cytomorphological features of <jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content> with the aim of highlighting salient diagnostic morphological features and differential diagnostic problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven cases of histologically proven <jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content> with available aspiration cytology smears were reviewed for the presence of distinguishing cytomorphological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The architectural arrangement of tumour cells was the most important diagnostic parameter. Cellular nests, three\u2010dimensional clusters dyscohesive aggregates and singly dispersed cells in the background were present in all cases. A unique \u2018garlanded appearance\u2019, owing to the peripheral orientation of nuclei within the tumour cell clusters, was noted (71.4%) along with the presence of basement membrane\u2010like material (71.4%). Transgressing vessels (85.7%) and endothelial wrapping of cell clusters (71.4%) were also noted. Interestingly, most cases lacked necrosis and mitotic activity that are included in the histological diagnostic criteria for <jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">PDTC<\/jats:styled-content> has considerable cytomorphological overlap with well\u2010differentiated thyroid tumours, this present study highlights certain cytomorphological features that may suggest the correct pre\u2010operative diagnosis, important for the appropriate management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12270","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T15:15:06Z","timestamp":1449933306000},"page":"176-184","source":"Crossref","is-referenced-by-count":26,"title":["Fine needle aspiration cytology features of poorly differentiated thyroid carcinoma"],"prefix":"10.1111","volume":"27","author":[{"given":"S.","family":"Purkait","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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