{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:14:48Z","timestamp":1772997288777,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A fine needle aspiration biopsy (<jats:styled-content style=\"fixed-case\">FNAB<\/jats:styled-content>) is the most valuable diagnostic procedure for pre\u2010operative discrimination of benign and malignant nodules. The Bethesda System for Reporting Thyroid Cytopathology provides standardised reporting and cytomorphological criteria in aspiration smears. The aim of the present study was to determine malignancy rates in nodules with different cytology results and evaluate the diagnostic value of Bethesda for variants of papillary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective analysis of 2534 cases with 5784 thyroid nodules, who underwent <jats:styled-content style=\"fixed-case\">FNAB<\/jats:styled-content> followed by surgery, were included in this study. <jats:styled-content style=\"fixed-case\">FNAB<\/jats:styled-content> was performed with ultrasonography guidance. Cytological diagnoses were classified as: non\u2010diagnostic (<jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>), benign, atypia of undetermined significance\/follicular lesions of undetermined significance (<jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content>), follicular neoplasm\/suspicious for follicular neoplasm (<jats:styled-content style=\"fixed-case\">FN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SFN<\/jats:styled-content>), suspicious for malignancy (<jats:styled-content style=\"fixed-case\">SUS<\/jats:styled-content>) and malignant. Histopathological diagnoses were classified into four groups: benign, <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>, follicular thyroid cancer and other types of thyroid cancer (including medullary thyroid cancer, undifferentiated thyroid cancer and thyroid tumours of uncertain malignant potential). Cases with <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> were further divided into four categories: conventional variant, follicular variant, aggressive variants (tall cell, diffuse sclerosing and columnar variant) and other variants (oncocytic, solid\/trabecular and warthin\u2010like variants). <jats:styled-content style=\"fixed-case\">FNAB<\/jats:styled-content> results were compared with histopathological results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Malignancy rates were 6.3%, 3.2%, 20.7%, 33.3%, 74.2% and 95.6% in the nodules with <jats:styled-content style=\"fixed-case\">ND<\/jats:styled-content>, benign, <jats:styled-content style=\"fixed-case\">AUS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FLUS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FN<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SFN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SUS<\/jats:styled-content> and malignant cytology results, respectively. Pre\u2010operative cytology was malignant or <jats:styled-content style=\"fixed-case\">SUS<\/jats:styled-content> in 56.6% of conventional, 24.3% of follicular, 92% of aggressive and 41.7% of other variants of histopathologically confirmed <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>. The difference between the groups was significant (<jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Bethesda classification is a reliable indicator of malignancy in nodules with different cytology results and seems to be very effective in predicting the malignancy for the nodules diagnosed with aggressive variant <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> on the final histological examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12384","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T04:12:42Z","timestamp":1474863162000},"page":"259-267","source":"Crossref","is-referenced-by-count":24,"title":["Bethesda classification is a valuable guide for fine needle aspiration reports and highly predictive especially for diagnosing aggressive variants of papillary thyroid carcinoma"],"prefix":"10.1111","volume":"28","author":[{"given":"B.","family":"Evranos","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. B.","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kilicarslan","sequence":"additional","affiliation":[{"name":"Department of Pathology Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Department of Surgery Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Ataturk Education and Research Hospital Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp031436"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgu024"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1385\/EP:16:4:323"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-9940-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0073"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22955"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020865"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04507.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.02.018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.10.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0854-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.15142308"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444669"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0243"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3180f61adc"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0265"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334218"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20195"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322365"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20830"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0425"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2012.01.001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2012.00988.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-014-0348-x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0612"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.43.4.207"},{"key":"e_1_2_7_34_1","first-page":"645","article-title":"Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid","volume":"37","author":"Leung CS","year":"1993","journal-title":"Acta Cytol"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353823"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326381"},{"key":"e_1_2_7_37_1","first-page":"352","article-title":"Fine needle aspiration cytology in a case of diffuse sclerosing carcinoma of the thyroid","volume":"34","author":"Caruso G","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331981"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20406"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21091"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/85.1.77"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200004)22:4<227::AID-DC5>3.0.CO;2-4"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326287"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0352"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2129-x"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:21:40Z","timestamp":1696260100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,25]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/cyt.12384"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12384","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,25]]}}}