{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:46Z","timestamp":1787014066206,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Fine needle cytology (\n FNC<\/jats:styled-content>\n ) of a parathyroid neoplasia (\n PN<\/jats:styled-content>\n ) is reliable, but needs to be confirmed by Parathormone (\n PTH<\/jats:styled-content>\n ) and Thyroglobulin (\n TG<\/jats:styled-content>\n ) immunoassay on needle washing or by immunocytochemistry (\n ICC<\/jats:styled-content>\n ) evaluation. The differentiation between parathyroid adenoma (\n PA<\/jats:styled-content>\n ), atypical adenoma (\n PAA<\/jats:styled-content>\n ) and carcinoma (\n PC<\/jats:styled-content>\n ) is difficult on histology or even impossible on\n FNC<\/jats:styled-content>\n . The aim of this study was to evaluate possible cytological criteria to classify FNC\u2010PN further.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Twenty\u2010three\n FNC<\/jats:styled-content>\n samples of\n PN<\/jats:styled-content>\n and parathyroid cysts were rather then have been reviewed. The series includes 18\n PN<\/jats:styled-content>\n s, 4 cysts and 1 Thyr3B (histologically diagnosed as\n PA<\/jats:styled-content>\n ). Cytological features were: cellularity, patterns (follicular, solid or papillary), clear, oncocytic, isolated cells, nuclear atypia, cytoplasmic inclusions, nucleoli and mitoses. Data were compared with the histological controls.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventeen\n PN<\/jats:styled-content>\n s, 2 cysts and 1 Thyr3B\n FNC<\/jats:styled-content>\n samples were histologically diagnosed as\n PA<\/jats:styled-content>\n (16),\n PAA<\/jats:styled-content>\n (2) and\n PC<\/jats:styled-content>\n (2). Two cysts and 1\n PN<\/jats:styled-content>\n were not confirmed histologically. Cytological features and incidences were: high cellularity (1\n PA<\/jats:styled-content>\n , 1\n PAA<\/jats:styled-content>\n , 2\n PC<\/jats:styled-content>\n s), follicular (8\n PA<\/jats:styled-content>\n s, 1\n PAA<\/jats:styled-content>\n ), solid (5\n PA<\/jats:styled-content>\n s, 1\n PC<\/jats:styled-content>\n ), papillary pattern (1\n PA<\/jats:styled-content>\n , 1\n PAA<\/jats:styled-content>\n , 1\n PC<\/jats:styled-content>\n ), clear cells (4\n PA<\/jats:styled-content>\n s, 1\n PAA<\/jats:styled-content>\n , 2\n PC<\/jats:styled-content>\n s), oncocytic cells (6\n PA<\/jats:styled-content>\n s, 1\n PAA<\/jats:styled-content>\n , 2\n PC<\/jats:styled-content>\n s), isolated cells (5\n PA<\/jats:styled-content>\n s, 2\n PAA<\/jats:styled-content>\n s, 2\n PC<\/jats:styled-content>\n s), nuclear atypia (2\n PA<\/jats:styled-content>\n s, 1\n PAA<\/jats:styled-content>\n , 2\n PC<\/jats:styled-content>\n s), cytoplasmic inclusions (4\n PA<\/jats:styled-content>\n s, 2\n PC<\/jats:styled-content>\n s), nucleoli (2\n PC<\/jats:styled-content>\n s) and mitoses (2\n PC<\/jats:styled-content>\n s).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Evident nucleoli and mitoses may suggest the differentiation between\n PA<\/jats:styled-content>\n and\n PC<\/jats:styled-content>\n . However, further investigations are required to confirm these preliminary observations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cyt.12413","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T01:46:38Z","timestamp":1487555198000},"page":"273-279","source":"Crossref","is-referenced-by-count":10,"title":["Fine needle cytology pre\u2010surgical differentiation of parathyroid neoplasms: Is it reliable?"],"prefix":"10.1111","volume":"28","author":[{"given":"A.","family":"Caleo","sequence":"first","affiliation":[{"name":"Azienda Ospedaliera Universitaria \u201cSan Giovanni di Dio e Ruggi d' Aragona\u201d Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vitale","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria \u201cSan Giovanni di Dio e Ruggi d' Aragona\u201d Salerno 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