{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:15:26Z","timestamp":1740125726178,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell\u2010type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid\u2010based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow\u2010up correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep<jats:sup>\u00ae<\/jats:sup> LBC workload. HPV testing was performed in each case using residual LBC material. Cytological\u2010histological correlations were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 15 LBC samples contained bizarre cells and tested positive for high\u2010risk HPV types. Ten of the 15 cases were identified as atypical squamous cells \u2010 cannot exclude an HSIL (ASC\u2010H) with secondary diagnosis of low\u2010grade squamous intraepithelial lesion (LSIL), while five cases were identified as high\u2010grade squamous intraepithelial lesion (HSIL), and a subsequent biopsy was recommended. Additionally, 13\/15 cases underwent cone biopsy or hysterectomy within 1\u201011 months, of which 10 showed histologically confirmed HSIL end\u2010points. LSIL was present in three cases. Bizarre cells were identified in the HSIL epithelium of five cone biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Identification of bizarre cells in LBC is straightforward and may facilitate diagnosis. The cytology of bizarre cells is associated with HSIL in cone biopsies. We recommend assigning LBC samples containing bizarre cells as ASC\u2010H with secondary diagnosis of LSIL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12494","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T10:02:56Z","timestamp":1511172176000},"page":"58-62","source":"Crossref","is-referenced-by-count":1,"title":["Significance of bizarre cells in cervical screening liquid\u2010based cytology: A prospective study of 15 cases"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-5641","authenticated-orcid":false,"given":"O.","family":"Ondi\u010d","sequence":"first","affiliation":[{"name":"Charles University Medical Faculty and Charles University Hospital Pilsen Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ferko","sequence":"additional","affiliation":[{"name":"Charles University Medical Faculty and Charles University Hospital Pilsen Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ki\u010dinov\u00e1","sequence":"additional","affiliation":[{"name":"Medicyt s.r.o. Ko\u0161ice Slovak Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bouda","sequence":"additional","affiliation":[{"name":"Charles University Medical Faculty and Charles University Hospital Pilsen Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Kinkorov\u00e1\u2010Lu\u0148\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Charles University Medical Faculty and Charles University Hospital Pilsen Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kupcov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. 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