{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:21:32Z","timestamp":1773296492799,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the corresponding cytological diagnoses, Gene Expression Classifier (<jats:styled-content style=\"fixed-case\">GEC<\/jats:styled-content>) results and ultrasound features of thyroid nodules diagnosed as <jats:styled-content style=\"fixed-case\">non\u2010invasive follicular thyroid neoplasms with papillary\u2010like nuclear features (NIFTP)<\/jats:styled-content>, as well as any coexisting pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of thyroid nodules histologically diagnosed as <jats:styled-content style=\"fixed-case\">NIFTP<\/jats:styled-content> at our institution between 1<jats:sup>st<\/jats:sup> April 2016 and 1<jats:sup>st<\/jats:sup> April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, <jats:styled-content style=\"fixed-case\">GEC<\/jats:styled-content> results, origin of sample (in\u2010house vs outside hospital) and any additional pathology identified in the resection specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The case cohort included 87 nodules diagnosed as <jats:styled-content style=\"fixed-case\">NIFTP<\/jats:styled-content> (size range: 1\u20107\u00a0cm, mean: 2.5\u00a0cm) from 82 patients (age range: 22\u201082, mean age: 50.4, M:F\u20141:4.1). Corresponding <jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content> results were available for 72 nodules (82.8%) and were categorised as follows: benign (n\u00a0=\u00a05, 6.9%), atypia of unknown significance\/follicular lesion of undetermined significance (n\u00a0=\u00a029, 40.3%), follicular neoplasm\/suspicious for follicular neoplasm\/follicular neoplasm with oncocytic features (n\u00a0=\u00a027, 37.5%), <jats:styled-content style=\"fixed-case\">suspicious for papillary thyroid carcinoma<\/jats:styled-content> (n\u00a0=\u00a06, 8.3%) and malignant (n\u00a0=\u00a05, 6.9%). <jats:styled-content style=\"fixed-case\">GEC<\/jats:styled-content> results were available for 32 (44.4%) nodules, with the majority of cases classified as suspicious (81.3%). On ultrasound, most of the nodules were predominantly solid (81.8%), vascular (93.8%), non\u2010calcified (86.5%), and either hypoechoic (44.9%) or isoechoic (38.8%). In addition to <jats:styled-content style=\"fixed-case\">NIFTP<\/jats:styled-content> and other benign findings in the background thyroid, 75 separate malignant tumours were identified in 38 (46.3%) patients, many of which were papillary thyroid microcarcinomas (86.5%) with lymph node metastases present in two cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of thyroid nodules histologically diagnosed as <jats:styled-content style=\"fixed-case\">NIFTP<\/jats:styled-content> have indeterminate cytology (77.8%) and are classified as suspicious (81.3%) by <jats:styled-content style=\"fixed-case\">GEC<\/jats:styled-content> testing. Taken together, these findings can guide clinicians toward a more conservative therapeutic approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12501","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T11:05:20Z","timestamp":1511348720000},"page":"488-494","source":"Crossref","is-referenced-by-count":29,"title":["Pre\u2010operative features of non\u2010invasive follicular thyroid neoplasms with papillary\u2010like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-9715","authenticated-orcid":false,"given":"S. J.","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"LiVolsi","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Montone","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Baloch","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine University of Pennsylvania Health System Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22138"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0369"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.112"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02773.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161632.OR"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21631"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0612"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167756"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21802"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0644"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21839"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0036"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3190"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181dbee07"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPEIE12POICULI"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.014"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21777"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw126"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0379"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21848"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-016-9437-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0583"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21292"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21879"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23709"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13263"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0214"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13473"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30180-2"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3120-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9476-5"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:36:05Z","timestamp":1695544565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cyt.12501"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12501","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}