{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:46:45Z","timestamp":1746406005821,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Differentiated cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content>) analogous to differentiated squamous intraepithelial neoplasia of the vulva is characterised by the proliferation of atypical cells limited to the basal\/parabasal layers. Exfoliative cytology of <jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content> has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A 46\u2010year\u2010old woman, with a history of normal Papanicolaou (Pap) smear up to 2\u00a0years prior to the occurrence of postcoital vaginal bleeding had two consecutive Pap smears, which only revealed atypical squamous cells of unknown significance (<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>). The subsequent cervical biopsy revealed <jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content>. The cone biopsy showed the invasive cervical squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>) that developed from the overlying <jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content>. Review of 32 consecutive cases of <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> revealed a second case of <jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> (Group 1) preceded by <jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content> suspicious for high\u2010grade neoplastic cells. In both cases, the <jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content> were keratinised atypical cells without koilocytosis. In addition, there were another seven cases showing focal <jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content> associated with extensive usual <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> (Group 2). In comparison with the remaining 24 cases with usual <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> (Group 3), Group 2 lesions occurred in younger patients (mean ages of 36\u00a0\u00b1\u00a03 vs 47\u00a0\u00b1\u00a09\u00a0years) and were associated with shorter intervals after the last normal Pap smears. Pap smears in Group 2 occasionally consisted only of ASCUS cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">dCIN<\/jats:styled-content> may occur in the cervix and accounts for a short interval of normal Pap smears and false negative or low\u2010grade Pap smears in <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12523","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T15:59:37Z","timestamp":1523030377000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differentiated cervical intraepithelial neoplasia\u2010associated invasive cervical squamous cell carcinoma as a source of major cytopathological and surgical pathological discrepancy in Papanicolaou smear screening tests"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-4235","authenticated-orcid":false,"given":"K. T.","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117485"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.6.791"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2283::AID-CNCR12>3.0.CO;2-D"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326673"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6449.896"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02360-13"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913512866"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2540643.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b0318134ea34"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.444"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.179"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000454"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/RQBN-Y51J-CJTK-P9H5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22865"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000291"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:25:19Z","timestamp":1695554719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/cyt.12523"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12523","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}