{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:18:29Z","timestamp":1776878309503,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Speed Fair Co. 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The sensitivity and specificity of the Imager System for predicting<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\u20103+) lesions among atypical squamous cells of undetermined significance samples were 80.00% and 70.53%, respectively, compared to 100% and 11.58% of<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test whilst the<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 genotyping increased the specificity to 77.89%. Among atypical squamous cells\u2010cannot exclude<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>, the sensitivity and specificity of Imager System for predicting<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\u20103+) lesions upon follow up were 82.86% and 33.33%%, respectively, compared to 97.14% and 4.76% of<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test and the<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 genotyping increased the specificity to 19.05%. Among<jats:styled-content style=\"fixed-case\">low\u2010grade squamous intraepithelial lesion<\/jats:styled-content>cases, the sensitivity and specificity of the Imager System for predicting<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\u20103+) lesions were 66.67% and 35.71%%, respectively, compared to 66.67% and 29.76% of<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test while<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 genotyping increased the specificity to 79.76%. The overall results of imager and high\u2010risk<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test agreed in 69.43% (268) of all samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The automated imager system and<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 genotyping can enhance the specificity of detecting<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>+ (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2\u20103+) lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12540","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T09:16:57Z","timestamp":1522055817000},"page":"267-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An automated quantitative<scp>DNA<\/scp>image cytometry system detects abnormal cells in cervical cytology with high sensitivity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0202-7050","authenticated-orcid":false,"given":"O. 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