{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:53:06Z","timestamp":1761562386223,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Aquaporin 1 (<jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural malignant mesothelioma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>). The aim of this study was to evaluate the expression of <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 and its prognostic value in a series of pleural <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> effusions, from a geographical area with high concentrations of fluoro\u2010edenite (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 25 <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> cases from Biancavilla (Italy), an area with high environmental concentrations of <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>. Cytological samples, cell\u2010blocks (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>), clinical and follow\u2010up data were available for all cases. Immunohistochemistry for calretinin, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6, <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>7 and <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>1 was used on <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> sections to confirm the cytological diagnosis of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">Immunohistochemistry<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 was performed and high expression was defined when \u226550% of tumour cells showed linear and circumferential membranous staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 16 men and nine women (median age: 67.5\u00a0years; range: 49\u201088\u00a0years). The median survival was 14\u00a0months (range 1.5\u201060\u00a0months), with a significant value (<jats:italic>P<\/jats:italic> = 0.006). All cases have been histologically confirmed and classified as epithelioid (16 cases), biphasic (seven cases) and sarcomatoid (two cases). <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 high expression has been observed in 16 cases. Comparing <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 high expression to the survival of corresponding patients, a significant association with a slight increased overall survival of 12\u00a0months has been demonstrated. Nine patients with a <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 score less than 50% showed a shorter median <jats:styled-content style=\"fixed-case\">overall survival<\/jats:styled-content> (7\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\u20101 high expression is detectable on cytological samples of <jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> with a prognostic value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12583","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T15:45:56Z","timestamp":1528299956000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aquaporin\u20101 expression in fluoro\u2010edenite\u2010induced mesothelioma effusions: An approach by cell\u2010block procedure"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Angelico","sequence":"first","affiliation":[{"name":"Department of Human Pathology of Adult and Developmental Age \u201cGaetano Barresi\u201d Unit of Pathological Anatomy University of Messina AOU Policlinico G. Martino Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2878-3572","authenticated-orcid":false,"given":"A.","family":"Ieni","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adult and Developmental Age \u201cGaetano Barresi\u201d Unit of Pathological Anatomy University of Messina AOU Policlinico G. Martino Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Department \u201cG.F. Ingrassia\u201d Section\u00a0of Pathologic Anatomy University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-5925","authenticated-orcid":false,"given":"P.","family":"Zeppa","sequence":"additional","affiliation":[{"name":"Pathological Anatomy AOU San Giovanni di Dio e Ruggi d'Aragona University of Salerno Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tuccari","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adult and Developmental Age \u201cGaetano Barresi\u201d Unit of Pathological Anatomy University of Messina AOU Policlinico G. 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