{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:44:32Z","timestamp":1758476672205,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Immunoglobulin (Ig)G4\u2010related disease is a recently described systemic immune\u2010mediated fibro\u2010inflammatory disease that frequently occurs in tumorous form. Herein, we elucidated the clinicopathological and cytological characteristics of IgG4\u2010related pleural lesions (<jats:styled-content style=\"fixed-case\">PLs<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Among 22 patients with fibro\u2010inflammatory PLs of idiopathic aetiology, eight cases were diagnosed as IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> and the remaining 14 as non\u2010IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> according to comprehensive diagnostic criteria for IgG4\u2010related disease. Cell block examination of pleural effusion (<jats:styled-content style=\"fixed-case\">CBPE<\/jats:styled-content>) was performed in five patients with IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> and in six with non\u2010IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>. Both groups were compared in terms of clinical presentation, laboratory data, histopathological features of resected pleura, and cytological features of pleural effusion (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> was the most common (six patients, 75%) clinical presentation of IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>. IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> comparatively showed significantly more frequent concomitant allergic disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.021), higher serum IgE levels (<jats:italic>P =<\/jats:italic> .012), higher adenosine deaminase levels in pleural fluid (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005), and rare spontaneous recovery without treatment (<jats:italic>P =<\/jats:italic> .046). The IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> group was histologically characterised by thicker fibrous pleura, storiform fibrosis, and infiltration of regulatory T cells, eosinophils and basophils. Using <jats:styled-content style=\"fixed-case\">CBPE<\/jats:styled-content>, IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> was cytologically distinct with numerous IgG4+ cells and eosinophils. The cytology of <jats:styled-content style=\"fixed-case\">CBPE<\/jats:styled-content> positively correlated with the histology of pleural tissue in the number of IgG4+ cells and eosinophils (<jats:italic>R<\/jats:italic>\u00a0=\u00a0.769 and .803, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> frequently presents with <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and is histologically and cytologically characterised by abundant infiltration of IgG4+ cells and eosinophils. We believe that <jats:styled-content style=\"fixed-case\">CBPE<\/jats:styled-content> with immunohistochemistry\/special staining could assist in the auxiliary diagnosis of IgG4\u2010<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12641","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T10:03:28Z","timestamp":1538820208000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological features of immunoglobulin G4\u2010related pleural lesions and diagnostic utility of pleural effusion cytology"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-9898","authenticated-orcid":false,"given":"Satomi","family":"Kasashima","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science Kanazawa University Kanazawa Japan"},{"name":"Department of Pathology Kanazawa Medical Center Kanazawa Japan"},{"name":"Department of Clinical Laboratory Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiro","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanazawa Medical Center Kanazawa Japan"},{"name":"Department of Clinical Laboratory Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Respiratory medicine Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Araya","sequence":"additional","affiliation":[{"name":"Department of Respiratory medicine Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department Thoracic surgery of National Hospital Organization Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutaka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department Thoracic surgery of National Hospital Organization Kanazawa Medical Center Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181bd535b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511080965"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2015.09.002"},{"key":"e_1_2_7_7_1","unstructured":""},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1098535"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.12.140"},{"key":"e_1_2_7_11_1","first-page":"30182","article-title":"IgG4\u2010related pleuritis with no other organ involvement","volume":"9629","author":"Kita T","year":"2018","journal-title":"Am J Med Sci"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.76.3.300"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12999"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002150"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3501-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4726"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206423"},{"issue":"19","key":"e_1_2_7_19_1","first-page":"18","article-title":"Immunoglobulin G4\u2010related pleuritis\u2014a case report","volume":"24","author":"Gajewska ME","year":"2016","journal-title":"Respir Med Case Rep"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0387-17"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011010062"},{"issue":"1","key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/rcr2.142","article-title":"IgG4\u2010related disease in asbestos\u2010related pleural disease","volume":"4","author":"Onishi Y","year":"2015","journal-title":"Respirol Case Rep"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3314"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000680"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8934-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-201303"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23617"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000173656.49557.48"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283413469"},{"issue":"2","key":"e_1_2_7_30_1","article-title":"IgG4\u2010related systemic disease presenting with pleural effusion, ascites and dilated cardiomyopathy","volume":"102","author":"Lee HJ","year":"2016","journal-title":"Tumori"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.12.057"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.12641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:54:22Z","timestamp":1694364862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/cyt.12641"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12641","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"2018-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}