{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:02:34Z","timestamp":1780671754287,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the performance of human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)\u2010based screening in the framework of an organised cervical cancer screening programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 46\u00a0708 women aged 35\u201060\u00a0years invited to the regional cervical cancer screening programme from 1 January 2012, to 31 December 2014, were enrolled. Overall, 17\u00a0770 women were screened by the Abbot RealTime hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test with cytology triage and 15\u00a0605 were screened by conventional (Papanicolaou, Pap) cytology. In both groups, women with at least low\u2010grade squamous intraepithelial lesions were referred directly for colposcopy, whereas <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive women with borderline or normal cytology were invited to intensified screening in the following year. In the Pap group, the indication for intensified follow\u2010up was borderline cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The attendance rate was similar in the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and Pap groups (72% and 71%, respectively). Overall, 6.0% of women in the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> group vs 6.4% in the Pap group were referred to intensified follow\u2010up (relative risk 0.94, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content>: 0.87\u20101.03). At the index screening years, the relative sensitivity of the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test with cytology triage vs conventional screening was 1.64 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.05\u20102.55) for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ and 2.06 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.17\u20103.41) for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+. The specificity of the hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> test with cytology triage for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ and <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+ was equal to that of the Pap screening (99.2% vs 99.2% for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ and 99.1% vs 99.1% for <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Due to its high sensitivity and specificity, primary hr<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing with cytology triage seems to be acceptable for cervical cancer screening in an organised setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12652","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T06:39:47Z","timestamp":1542091187000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Implementation of <scp>HPV<\/scp>\u2010based cervical cancer screening in an organised regional screening programme: 3\u00a0years of experience"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-0385","authenticated-orcid":false,"given":"Olga","family":"Veijalainen","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics P\u00e4ij\u00e4t H\u00e4meen Central Hospital Lahti Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kares","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Kujala","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Vuento","sequence":"additional","affiliation":[{"name":"Department of Microbiology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Osuala","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and obstetrics Municipal Hospital of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Tirkkonen","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Ltd Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Luukkaala","sequence":"additional","affiliation":[{"name":"Science Centre Tampere University Hospital and Health Sciences Faculty of Social Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Fimlab Laboratories Ltd Tampere Finland"},{"name":"Department of Pathology Faculty of Medicine and Life Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"M\u00e4enp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Tampere University Hospital and Faculty of Medicine and Life Sciences University of Tampere Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"NORDCAN.http:\/\/www-dep.iarc.fr\/NORDCAN\/FI\/frame.asp. 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