{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:56:48Z","timestamp":1747184208663,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K08732"],"award-info":[{"award-number":["17K08732"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Acute and lymphoma type adult T\u2010cell leukaemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>) patients show an aggressive clinical course. While some clinical signs indicate good prognosis, definitive cytohistological prognostic factors have yet to be described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We classified 65 <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> patients into three groups by tumour cell size and nuclear pleomorphism on fine\u2010needle aspiration and tumour touch smear samples. Semi\u2010quantitative analysis of background small lymphocytes, reactive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20\u2010positive B cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010positive T cells was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one patients had pleomorphic lymphoma with predominantly medium\u2010sized cells and coarse granular nuclei. Another 24 patients showed pleomorphic large cell lymphoma with stippled chromatin. The remaining 10 demonstrated monomorphic large lymphoma cells with fine granular chromatin. Patients with pleomorphic lymphoma with medium\u2010sized cells showed significantly higher serum lactate dehydrogenase and lower <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 and C\u2010<jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> expression in lymphoma cells than the other two groups (<jats:italic>P<\/jats:italic> = .0216, <jats:italic>P<\/jats:italic> &lt; 0.01, respectively). Patients with pleomorphic medium\u2010sized <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> had few usual small lymphocytes observed on routine morphological examination and showed less concurrent detection of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20\u2010positive B cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010positive T cells, both of which were lower than in the other two groups (<jats:italic>P =<\/jats:italic> .006, <jats:italic>P =<\/jats:italic> .019, respectively). Furthermore, <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> patients with predominantly medium\u2010sized lymphocytes exhibited a worse prognosis than patients with pleomorphic large cells (<jats:italic>P =<\/jats:italic> .0197). Background small lymphocytes and concurrent detection of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20\u2010positive B cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010positive T cells may thus be good prognostic factors (<jats:italic>P =<\/jats:italic> .011, <jats:italic>P =<\/jats:italic> .021, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Morphological features, size of neoplastic cells and background non\u2010neoplastic lymphocyte (B cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010positive T cells) volume appear to influence the prognosis of patients with aggressive\u2010type <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12693","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T10:57:22Z","timestamp":1553511442000},"page":"402-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytological tumour cell characteristics and reactive small lymphocytes influence patient prognosis in acute and lymphoma type adult T\u2010cell leukaemia\/lymphoma"],"prefix":"10.1111","volume":"30","author":[{"given":"Katsumi","family":"Kobata","sequence":"first","affiliation":[{"name":"Pathology Laboratory Fukuoka University Hospital Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Mihashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Fukuoka University Fukuoka Japan"},{"name":"Department of Otolaryngology Faculty of Medicine Fukuoka 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