{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:18:09Z","timestamp":1781356689262,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Extranodal natural killer\/T\u2010cell lymphoma, nasal type (<jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content>) is an aggressive extranodal lymphoma of <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\u2010cell or T\u2010cell lineage. Its clinical features overlap with those of several sinonasal mass lesions. While the histopathological features are well described, diagnosis is often difficult, owing to presence of extensive coagulative necrosis, so that repeated biopsies may sometimes be necessary for correct diagnosis. Literature on cytological findings of <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytomorphological features of cases of histologically confirmed <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> having corresponding cytology samples were reviewed retrospectively, to identify distinctive features that could possibly suggest this entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aspirates from five patients were studied: four from cervical nodes, one from cheek swelling and one from pleural fluid. Two aspirates were reported as positive for malignancy, two as atypical lymphoid proliferation and one was non\u2010diagnostic. Pleural fluid was reported as malignant, favouring a diagnosis of carcinoma. On cytology, aspirates showed medium to large cells with folded, indented nuclei and abundant pale cytoplasm, some with <jats:italic>tongue\u2010like<\/jats:italic> cytoplasmic protrusions. A distinctive feature was presence of large loose clusters of tumour cells with arborising capillaries running through them. Interestingly, necrosis was consistently absent. Subsequent biopsies from palate (three cases) and nasal masses (two cases) confirmed the diagnosis of <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Suspicion of <jats:styled-content style=\"fixed-case\">ENKTL<\/jats:styled-content> on cytology is crucial for timely diagnosis to avoid diagnostic delay, especially when only highly necrotic biopsy samples are available. Awareness of distinctive cytomorphological features is required to make fine needle aspiration an effective diagnostic tool for initial diagnosis and for evaluation of possible recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12705","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T04:40:50Z","timestamp":1555130450000},"page":"393-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Spectrum of cytomorphological features of extranodal NK\/T\u2010cell lymphoma, nasal type"],"prefix":"10.1111","volume":"30","author":[{"given":"Kanwalpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-1099","authenticated-orcid":false,"given":"Aanchal","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishu","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirabu","family":"Sakthivel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head Neck Surgery All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirom Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head Neck Surgery All India Institute of 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