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New knowledge on well\u2010defined entities further enlightens the mechanisms of lymphomagenesis, which are more complex and multifactorial than once believed. Therapies are also more complex because traditional clinical trials have been integrated with new drugs and compounds with unique mechanisms of actions against distinct molecular targets. As lymphoma acquires additional genetic and phenotypic features over the time, pathological assessment is also necessary. Histological evaluation and tissue collection by surgical biopsies are necessary for phenotypical and molecular purposes; however, these are demanding procedures for both the patient and the health care system. At the same time, the choice of the best treatment for a specific entity, in different phases and different patients requires information that may not be available when the biopsy is performed. Fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) is successfully used in lymph nodes (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>s) in combination with different ancillary techniques and might be used to assess the phenotypic and genetic profile of specific targets and to get key information for therapy, in different phases and stages of the disease, with the option to re\u2010check the same target over time, without surgical excision. This brief review describes <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> diagnostic criteria, current therapies for lymphomas and the potential role of <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> in selecting non\u2010Hodgkin lymphomas patients for specific targeted treatments.<\/jats:p>","DOI":"10.1111\/cyt.12708","type":"journal-article","created":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T13:17:53Z","timestamp":1555766273000},"page":"348-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lymph node fine\u2010needle cytology in the era of personalised medicine. 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